Vaginal micronized progesterone versus the levonorgestrel-releasing intrauterine system for treatment of non-atypical endometrial hyperplasia: A randomized controlled trial

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dc.authorid0000-0002-4940-8862
dc.authorid0000-0001-9344-808X
dc.contributor.authorGezer, Sener
dc.contributor.authorKole, Emre
dc.contributor.authorAksoy, Lale
dc.date.accessioned2026-01-24T12:30:49Z
dc.date.available2026-01-24T12:30:49Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObjectiveTo compare the efficiency of vaginal micronized progesterone (VMP) with the levonorgestrel-releasing intrauterine system (LNG-IUS) in patients with non-atypical endometrial hyperplasia. A validated Menorrhagia Impact Questionnaire (MIQ) was used to assess the quality of life before and after the procedure. MethodsIn this prospective trial, 144 women were randomly assigned to the VMP or LNG-IUS group. The primary endpoint was the regression rate of endometrial hyperplasia after 3 months of treatment. The protocol was approved by the institutional ethics committee and registered at (NCT03992937). ResultsIn all, 138 patients were analyzed. The regression rate was not significantly different between the groups (95.8% with LNG-IUS vs. 90.8% with VMP; P = 0.194). Differences between pre- and post-treatment MIQ scores were similar, except that better scores were obtained in the VMP group for the perception of the amount of blood loss (P = 0.035). ConclusionVMP is as effective as the LNG-IUS as a local treatment of endometrial hyperplasia without atypia. Trial registration.
dc.identifier.doi10.1002/ijgo.14632
dc.identifier.endpage666
dc.identifier.issn0020-7292
dc.identifier.issn1879-3479
dc.identifier.issue2
dc.identifier.pmid36527262
dc.identifier.scopus2-s2.0-85146277019
dc.identifier.scopusqualityQ1
dc.identifier.startpage661
dc.identifier.urihttps://doi.org/10.1002/ijgo.14632
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5454
dc.identifier.volume161
dc.identifier.wosWOS:000912807400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofInternational Journal of Gynecology & Obstetrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectlevonorgestrel-releasing intrauterine system
dc.subjectnon-atypical endometrial hyperplasia
dc.subjectvaginal micronized progesterone
dc.subjectBayer
dc.titleVaginal micronized progesterone versus the levonorgestrel-releasing intrauterine system for treatment of non-atypical endometrial hyperplasia: A randomized controlled trial
dc.typeArticle

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