Within- and between-subject biological variation data for whole blood HbA1c from 38 apparently healthy Turkish subjects

Basit Öğe Kaydı
dc.contributor.authorKeles, Murat
dc.contributor.authorSeker, Gonul Unver
dc.date.accessioned2026-01-24T12:31:25Z
dc.date.available2026-01-24T12:31:25Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractHbA1c plays an important role in the diagnosis and treatment of diabetes and is a valuable biomarker for evaluating glycemic control and predicting the risk of vascular complications. The study aimed to determine the biological variation (BV) for HbA1c and thereby contribute to analytical performance specifications, reference change values, and index of individuality. Fasting venous whole blood samples were collected from 38 presumably healthy subjects (20 females, 18 males) once a week for ten weeks, and analyzed in duplicate using the Roche Cobas c501 analyzer. BioVar, an online R-based biological variation analysis tool, was used for the statistical analysis. BV values were obtained by analysis of variance (ANOVA) after outlier detection, normality tests, steady-state, and homogeneity checks. The within-subject biological variation for HbA1c was 2.9%, and the between-subject biological variation was 7.9%. The index of the individuality of HbA1c was 0.37. Derived desirable analytical goals for imprecision, bias, total allowable error, and maximum expanded allowable measurement uncertainty were 1.4%, 1.8%, 4.2%, and 2.9% respectively. The reference change value is more appropriate for interpreting HbA1c results than a population-based reference interval.
dc.identifier.doi10.1080/00365513.2024.2439394
dc.identifier.endpage539
dc.identifier.issn0036-5513
dc.identifier.issn1502-7686
dc.identifier.issue7-8
dc.identifier.pmid39679793
dc.identifier.scopus2-s2.0-85212286984
dc.identifier.scopusqualityQ3
dc.identifier.startpage535
dc.identifier.urihttps://doi.org/10.1080/00365513.2024.2439394
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5854
dc.identifier.volume84
dc.identifier.wosWOS:001378478800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofScandinavian Journal of Clinical & Laboratory Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectProtein glycation including HbA1c
dc.subjectbiological variation
dc.subjectLaboratory management
dc.subjectanalytical performance
dc.subjectquality assurance and quality improvement
dc.titleWithin- and between-subject biological variation data for whole blood HbA1c from 38 apparently healthy Turkish subjects
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu