Comparison of the cytotoxic effects of different Origanum majorana extracts on lung cancer cells

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dc.contributor.authorErdogan, Ayse
dc.date.accessioned2026-01-24T12:29:11Z
dc.date.available2026-01-24T12:29:11Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractThe determination that compounds used for chemotherapeutic purposes in cancer treatment cause cytotoxic effects on healthy cells as well as target cells has led researchers to work on reducing treatment-related toxicity, and accordingly, research on the effectiveness of herbal resources in cancer treatment has gained importance. In our study, ethanol, methanol and chloroform extracts were obtained from the aboveground parts of Origanum majorana L. (O. majorana) and their cytotoxic effects on A-549 cells (non-small cell lung cancer (NSCLC)) were investigated using MTT test. Additionally, the free radical scavenging activities of extracts were demonstrated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) test. It has been shown that cytotoxic effects of extracts increased depending on concentrations on A-549 cells. It was determined that methanol, ethanol and chloroform extracts of O. majorana caused an increase in the activity of lactate dehydrogenase (LDH), and apoptotic enzyme, caspase-3 activity, compared to the control. It has been demonstrated that methanol, ethanol, and chloroform extracts of O. majorana had membrane damaging and apoptotic effects on A-549.
dc.identifier.doi10.12991/jrespharm.1660997
dc.identifier.endpage515
dc.identifier.issn2630-6344
dc.identifier.issue2
dc.identifier.scopus2-s2.0-105011585387
dc.identifier.scopusqualityQ3
dc.identifier.startpage507
dc.identifier.trdizinid1339262
dc.identifier.urihttps://doi.org/10.12991/jrespharm.1660997
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1339262
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5190
dc.identifier.volume29
dc.identifier.wosWOS:001489105500003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherMarmara Univ, Fac Pharmacy
dc.relation.ispartofJournal of Research in Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectOriganum majorana
dc.subjectapoptosis
dc.subjectantioxidant
dc.subjectDPPH
dc.titleComparison of the cytotoxic effects of different Origanum majorana extracts on lung cancer cells
dc.typeArticle

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