Infection with COVID-19 is no longer a public emergency: But what about degenerative dementia?

Basit Öğe Kaydı
dc.authorid0000-0002-3047-3613
dc.authorid0000-0002-9704-6173
dc.authorid0000-0002-2306-5937
dc.authorid0000-0002-6165-2569
dc.contributor.authorYulug, Burak
dc.contributor.authorAyyildiz, Behcet
dc.contributor.authorAyyildiz, Sevilay
dc.contributor.authorSayman, Dila
dc.contributor.authorSalar, Ali Behram
dc.contributor.authorCankaya, Seyda
dc.contributor.authorOzdemir Oktem, Ece
dc.date.accessioned2026-01-24T12:30:49Z
dc.date.available2026-01-24T12:30:49Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractAlthough no longer considered a public health threat, post-COVID cognitive syndrome continues to impact on a considerable proportion of individuals who were infected with COVID-19. Recent studies have also suggested that COVID may be represent a critical risk factor for the development of Alzheimer's disease (AD). We compared 17 COVID patients with 20 controls and evaluated the effects of COVID-19 on general cognitive performance, hippocampal volume, and connections using structural and seed-based connectivity analysis. We showed that COVID patients exhibited considerably worse cognitive functioning and increased hippocampal connectivity supported by the strong correlation between hippocampal connectivity and cognitive scores. Our findings of higher hippocampal connectivity with no observable hippocampal morphological changes even in mild COVID cases may be represent evidence of a prestructural compensatory mechanism for stimulating additional neuronal resources to combat cognitive dysfunction as recently shown for the prodromal stages of degenerative cognitive disorders. Our findings may be also important in light of recent data showing that other viral infections as well as COVID may constitute a critical risk factor for the development of AD. To our knowledge, this is the first study that investigated network differences in COVID patients, with a particular focus on compensatory hippocampal connectivity.
dc.description.sponsorshipThe authors of this work are grateful to Istanbul Medipol University, Research Institute for Health and Technologies (SABITA). This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.; Research Institute for Health and Technologies (SABITA)
dc.description.sponsorshipThe authors of this work are grateful to Istanbul Medipol University, Research Institute for Health and Technologies (SABITA). This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
dc.identifier.doi10.1002/jmv.29072
dc.identifier.issn0146-6615
dc.identifier.issn1096-9071
dc.identifier.issue9
dc.identifier.pmid37724347
dc.identifier.scopus2-s2.0-85171575554
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/jmv.29072
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5461
dc.identifier.volume95
dc.identifier.wosWOS:001079032200003
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Medical Virology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectcognition
dc.subjectCOVID infection
dc.subjectfMRI
dc.subjecthippocampal connectivity
dc.titleInfection with COVID-19 is no longer a public emergency: But what about degenerative dementia?
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu