Beneficial Effects of Selenium on Kidney Injury via Nf-Kb and Aquaporin-1 Levels

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dc.authorid0000-0002-2249-4668
dc.authorid0000-0002-4671-9315
dc.authorid0000-0002-9984-294X
dc.authorid0000-0002-5138-5583
dc.authorid0000-0002-6337-8962
dc.contributor.authorCandan, B.
dc.contributor.authorKarakuyu, N. F.
dc.contributor.authorGulle, K.
dc.contributor.authorSarman, E.
dc.contributor.authorKaratopuk, D. Ulusoy
dc.date.accessioned2026-01-24T12:30:59Z
dc.date.available2026-01-24T12:30:59Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractSystemic inflammation is a serious condition that can affect various tissues and organs, such as the kidneys, and can be life-threatening. Selenium (Se) is an antioxidant and anti-inflammatory trace element. In this study, we aimed to examine the effects of Se, which has antioxidant and anti-inflammatory properties, on lipopolysaccharide (LPS)-induced kidney damage to maintain aquaporin-1 (AQP-1) levels. Four experimental rat groups (n = 8) consisting of the control, LPS alone, LPS + Se, and Se alone were so applied for 7 consecutive days. Upon sacrifice, histopathological results, diagnostic markers of kidney functions, oxidative stress, and inflammation were analyzed. Our results showed that LPS induced mononuclear cell infiltration, cellular residue, and protein deposition in the kidney proximal tubules, and also decreased total antioxidant status levels and increased total antioxidant status and oxidative stress index values. LPS increased the level of creatinine, increased the level of Nuclear Factor kappa B, which has an important role in the inflammation process, and decreased the levels of AQP-1 due to the damage it caused. Se has shown its effect by reversing all these situations. This data suggests that Se can be used as an additive to mitigate LPS-induced toxicity in the kidney.
dc.identifier.doi10.1007/s12011-023-03928-1
dc.identifier.endpage3661
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue8
dc.identifier.pmid37910264
dc.identifier.scopus2-s2.0-85175373896
dc.identifier.scopusqualityQ1
dc.identifier.startpage3653
dc.identifier.urihttps://doi.org/10.1007/s12011-023-03928-1
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5573
dc.identifier.volume202
dc.identifier.wosWOS:001091843000003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectAquaporin-1
dc.subjectInflammation
dc.subjectKidney
dc.subjectLipopolysaccharide
dc.subjectSelenium
dc.titleBeneficial Effects of Selenium on Kidney Injury via Nf-Kb and Aquaporin-1 Levels
dc.typeArticle

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