Smoking affects global and regional brain entropy in depression patients regardless of depression: Preliminary findings

Basit Öğe Kaydı
dc.authorid0000-0002-2306-5937
dc.contributor.authorVelioglu, Halil Aziz
dc.contributor.authorYildiz, Sultan
dc.contributor.authorOzdemir-Oktem, Ece
dc.contributor.authorCankaya, Seyda
dc.contributor.authorLundmark, Anton Kjell
dc.contributor.authorOzsimsek, Ahmet
dc.contributor.authorHanoglu, Lutfu
dc.date.accessioned2026-01-24T12:31:16Z
dc.date.available2026-01-24T12:31:16Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObjective: This study examines the effect of smoking on global and regional brain entropy in patients with Major Depressive Disorder (MDD), aiming to elucidate the relationship between smoking habits and brain network complexity in depression. Methods: The study enrolled 24 MDD patients, divided into smokers and non-smokers, from Alanya Alaaddin Keykubat University and Istanbul Medipol University. Resting-state fMRI data were acquired and processed. The complexity of neuronal activity was assessed using dispersion entropy, with statistical significance determined by a suite of tests including Kolmogorov -Smirnov, Student 's t-test, and Mann -Whitney U test. Results: The smoking cohort exhibited higher global brain entropy compared to the non-smoking group (p = 0.033), with significant differences in various brain networks, indicating that smoking may alter global brain activity and network dynamics in individuals with MDD. Conclusion: The study provides evidence that smoking is associated with increased brain entropy in MDD patients, suggesting that chronic smoking may influence cognitive and emotional networks. This underscores the importance of considering smoking history in the treatment and prognosis of MDD. The findings call for further research to understand the mechanistic links between smoking, brain entropy, and depression.
dc.identifier.doi10.1016/j.jpsychires.2024.07.002
dc.identifier.endpage152
dc.identifier.issn0022-3956
dc.identifier.issn1879-1379
dc.identifier.pmid39018709
dc.identifier.scopus2-s2.0-85198550629
dc.identifier.scopusqualityQ1
dc.identifier.startpage147
dc.identifier.urihttps://doi.org/10.1016/j.jpsychires.2024.07.002
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5753
dc.identifier.volume177
dc.identifier.wosWOS:001273201900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofJournal of Psychiatric Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectMajor depressive disorder
dc.subjectSmoking
dc.subjectfMRI
dc.subjectBrain entropy
dc.titleSmoking affects global and regional brain entropy in depression patients regardless of depression: Preliminary findings
dc.typeArticle

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