Investigation of The Effect of Adalimumab on Experimental Brain Injury in Mice
| dc.contributor.author | Gunal, Mehmet Yalcin | |
| dc.contributor.author | Çankaya, Seyda | |
| dc.contributor.author | Tönük, Şükrü Burak | |
| dc.contributor.author | Özdemir, Ekrem Musa | |
| dc.contributor.author | Şakul, Ayşe Arzu Sayın | |
| dc.date.accessioned | 2026-01-24T12:00:51Z | |
| dc.date.available | 2026-01-24T12:00:51Z | |
| dc.date.issued | 2019 | |
| dc.department | Alanya Alaaddin Keykubat Üniversitesi | |
| dc.description.abstract | Aim: We aimed to investigate the neuroprotective role of adalimumab based onthe hypothesis that \"TNF-alpha inhibitor adalimumab may affect inflammationrelated neuronal injury due to its anti-inflammatory effect\".Methods: To investigate the effects of adalimumab, we induced brain injury inmice using a cold trauma model and evaluated the underlying cell survival/ deathmechanisms via cresyl violet and calculated infarct/edema volume with imageanalyze system.Results: Although our data indicated a tendency to decreased infarct and edemavolume, these findings are not significant statistically.Conclusion: To the best of our knowledge, this is the first study evaluating theneuroprotective effect of adalimumab on injured neurons. | |
| dc.identifier.doi | 10.30565/medalanya.632455 | |
| dc.identifier.endpage | 310 | |
| dc.identifier.issn | 2587-0319 | |
| dc.identifier.issue | 3 | |
| dc.identifier.startpage | 306 | |
| dc.identifier.trdizinid | 376949 | |
| dc.identifier.uri | https://search.trdizin.gov.tr/tr/yayin/detay/376949 | |
| dc.identifier.uri | https://doi.org/10.30565/medalanya.632455 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12868/3774 | |
| dc.identifier.volume | 3 | |
| dc.indekslendigikaynak | TR-Dizin | |
| dc.language.iso | en | |
| dc.relation.ispartof | Acta Medica Alanya | |
| dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.snmz | KA_TR-Dizin_20260121 | |
| dc.subject | Tıbbi Araştırmalar Deneysel,Genel ve Dahili Tıp,Patoloji | |
| dc.title | Investigation of The Effect of Adalimumab on Experimental Brain Injury in Mice | |
| dc.type | Article |
