Investigation of The Effect of Adalimumab on Experimental Brain Injury in Mice
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Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: We aimed to investigate the neuroprotective role of adalimumab based onthe hypothesis that \"TNF-alpha inhibitor adalimumab may affect inflammationrelated neuronal injury due to its anti-inflammatory effect\".Methods: To investigate the effects of adalimumab, we induced brain injury inmice using a cold trauma model and evaluated the underlying cell survival/ deathmechanisms via cresyl violet and calculated infarct/edema volume with imageanalyze system.Results: Although our data indicated a tendency to decreased infarct and edemavolume, these findings are not significant statistically.Conclusion: To the best of our knowledge, this is the first study evaluating theneuroprotective effect of adalimumab on injured neurons.
Açıklama
Anahtar Kelimeler
Tıbbi Araştırmalar Deneysel,Genel ve Dahili Tıp,Patoloji
Kaynak
Acta Medica Alanya
WoS Q Değeri
Scopus Q Değeri
Cilt
3
Sayı
3
