Fabrication and characterization of chlorhexidine gluconate loaded poly(vinyl alcohol)/45S5 nano-bioactive glass nanofibrous membrane for guided tissue regeneration applications

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dc.authorid0000-0001-9015-3104
dc.authorid0000-0002-6871-2202
dc.contributor.authorKececiler-Emir, Ceren
dc.contributor.authorBasaran-Elalmis, Yeliz
dc.contributor.authorSahin, Yesim Muge
dc.contributor.authorBulus, Erdi
dc.contributor.authorYucel, Sevil
dc.date.accessioned2026-01-24T12:30:49Z
dc.date.available2026-01-24T12:30:49Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractPolymeric barrier membranes are used in periodontal applications to prevent fibroblastic cell migration into the cavities of bone tissue and to properly guide the proliferation of tissues. In this study, the fabrication, characterization, bioactivity, and in vitro biological properties of polyvinyl alcohol-based nanofibrous membranes containing nano-sized 45S5 bioactive glass (BG) loaded with chlorhexidine (CH) gluconate with biocompatible, bioactive, and antibacterial properties for using as dental barrier membranes were investigated. Nanofibrous membranes with an average fiber diameter, pore size, and porosity of 210 nm, 24.73 mu m, and 12.42%, respectively, were loaded with 1% and 2% CH, and the release profile was investigated. The presence of BG in the membranes promoted fibroblastic proliferation and the presence of CH provided antibacterial properties. Nanofibrous membranes exhibit a high ability to restrict bacterial growth while fulfilling the necessary conditions for use as a dental barrier thanks to their low swelling rates, significant surface bioactivities, and appropriate degradation levels.
dc.description.sponsorshipYildiz Technical University Scientific Research Projects Coordination Unit [FBA-2021-4533]
dc.description.sponsorshipYildiz Technical University Scientific Research Projects Coordination Unit, Grant/Award Number: FBA-2021-4533
dc.identifier.doi10.1002/bip.23562
dc.identifier.issn0006-3525
dc.identifier.issn1097-0282
dc.identifier.issue10
dc.identifier.pmid37421643
dc.identifier.scopus2-s2.0-85164602693
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/bip.23562
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5442
dc.identifier.volume114
dc.identifier.wosWOS:001025642400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofBiopolymers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectIn-Vitro Bioactivity
dc.subjectPhysicochemical Properties
dc.subjectMechanical-Properties
dc.subjectCross-Linking
dc.subjectElectrospun
dc.subject45s5
dc.subjectScaffolds
dc.subjectNanoparticles
dc.subjectDigluconate
dc.subjectDegradation
dc.titleFabrication and characterization of chlorhexidine gluconate loaded poly(vinyl alcohol)/45S5 nano-bioactive glass nanofibrous membrane for guided tissue regeneration applications
dc.typeArticle

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