Cerebral volume alterations in late-onset monocular blindness-a volumetric imaging study

Basit Öğe Kaydı
dc.contributor.authorOktem, E. O.
dc.contributor.authorAslan, F.
dc.contributor.authorOzen, O.
dc.date.accessioned2026-01-24T12:26:44Z
dc.date.available2026-01-24T12:26:44Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractAim: An increasing number of studies have demonstrated that persons who are blind from birth may have some alterations in the brain, although the neuroanatomical and functional effects of late-onset monocular blindness (LMB) are not well known. In our study, we aimed to measure the volumes of cerebral structures in LMB individuals and compare with healthy subjects, in order to investigate the underlying neuro-adaptive mechanisms. Material and methods: A study group with 13 LMB patients due to an isolated ocular trauma and a control group with the 13 age- and sexmatched healthy individuals were evaluated. All participants underwent a full ophthalmological examination. Brain MRI examination of the participants was performed using a 1.5-T MRI device and volumetric data were analyzed through the MRIvolBrain and MRICloud procedures. Results: Compared with healthy controls, individuals with LMB showed significantly increased accumbens volumes and decreased volumes of the middle occipital gyrus and cuneus (Cu). In the statistical analysis between the blind eyes and sighted eyes of LMB individuals, the ratio of cornu ammonis to the intracranial cavity and Cu volumes were low on the blind side. In a comparison of cerebral volumes on the sighted side of the LMB group and ipsilateral cerebral volumes of controls, we found lower supramarginal gyrus volumes, higher subiculum volumes in the LMB group than in the control group. Conclusion: LMB may lead to structural alterations in specifi c brain regions, such as the limbic system and visual cortex, which play a potential role in neuro-adaptive mechanisms.
dc.identifier.doi10.48095/cccsnn2023121
dc.identifier.endpage127
dc.identifier.issn1210-7859
dc.identifier.issn1802-4041
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85162746675
dc.identifier.scopusqualityQ3
dc.identifier.startpage121
dc.identifier.urihttps://doi.org/10.48095/cccsnn2023121
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4876
dc.identifier.volume86
dc.identifier.wosWOS:000996022700001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherCzech Medical Soc
dc.relation.ispartofCeska A Slovenska Neurologie A Neurochirurgie
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectmonocular blindness
dc.subjectlate-onset
dc.subjectbrain
dc.subjectstructural imaging
dc.subjectcerebral volumes
dc.titleCerebral volume alterations in late-onset monocular blindness-a volumetric imaging study
dc.title.alternativeZm?ny v mozkovém objemu p?i monokulární slepot? s pozdním nástupem – studie volumetrického zobrazení
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu