Cerebral volume alterations in late-onset monocular blindness-a volumetric imaging study
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Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Czech Medical Soc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: An increasing number of studies have demonstrated that persons who are blind from birth may have some alterations in the brain, although the neuroanatomical and functional effects of late-onset monocular blindness (LMB) are not well known. In our study, we aimed to measure the volumes of cerebral structures in LMB individuals and compare with healthy subjects, in order to investigate the underlying neuro-adaptive mechanisms. Material and methods: A study group with 13 LMB patients due to an isolated ocular trauma and a control group with the 13 age- and sexmatched healthy individuals were evaluated. All participants underwent a full ophthalmological examination. Brain MRI examination of the participants was performed using a 1.5-T MRI device and volumetric data were analyzed through the MRIvolBrain and MRICloud procedures. Results: Compared with healthy controls, individuals with LMB showed significantly increased accumbens volumes and decreased volumes of the middle occipital gyrus and cuneus (Cu). In the statistical analysis between the blind eyes and sighted eyes of LMB individuals, the ratio of cornu ammonis to the intracranial cavity and Cu volumes were low on the blind side. In a comparison of cerebral volumes on the sighted side of the LMB group and ipsilateral cerebral volumes of controls, we found lower supramarginal gyrus volumes, higher subiculum volumes in the LMB group than in the control group. Conclusion: LMB may lead to structural alterations in specifi c brain regions, such as the limbic system and visual cortex, which play a potential role in neuro-adaptive mechanisms.
Açıklama
Anahtar Kelimeler
monocular blindness, late-onset, brain, structural imaging, cerebral volumes
Kaynak
Ceska A Slovenska Neurologie A Neurochirurgie
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
86
Sayı
2
