Characteristics and predictors of chronic kidney disease in children with myelomeningocele: a nationwide cohort study

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dc.authorid0000-0003-2191-1981
dc.authorid0000-0002-8000-361X
dc.authorid0000-0002-6280-4587
dc.authorid0000-0002-0686-9714
dc.authorid0000-0001-5217-5847
dc.authorid0000-0003-4410-0444
dc.contributor.authorDogan, Cagla Serpil
dc.contributor.authorTaner, Sevgin
dc.contributor.authorTiryaki, Betul Durucu
dc.contributor.authorAlaygut, Demet
dc.contributor.authorOzkayin, Nese
dc.contributor.authorKara, Aslihan
dc.contributor.authorGencler, Aylin
dc.date.accessioned2026-01-24T12:30:53Z
dc.date.available2026-01-24T12:30:53Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractBackground Myelomeningocele (MMC) is highly prevalent in developing countries, and MMC-related neurogenic bladder is an important cause of childhood chronic kidney disease (CKD). This nationwide study aimed to evaluate demographic and clinical features of pediatric patients with MMC in Turkey and risk factors associated with CKD stage 5.Methods Data from children aged 0-19 years old, living with MMC in 2022, were retrospectively collected from 27 pediatric nephrology centers. Patients > 1 year of age without pre-existing kidney abnormalities were divided into five groups according to eGFR; CKD stages 1-5. Patients on dialysis, kidney transplant recipients, and those with eGFR < 15 ml/min/1.73 m2 but not on kidney replacement therapy at time of study constituted the CKD stage 5 group.Results A total of 911 (57.8% female) patients were enrolled, most of whom were expectantly managed. Stages 1-4 CKD were found in 34.3%, 4.2%, 4.1%, and 2.4%, respectively. CKD stage 5 was observed in 5.3% of patients at median 13 years old (range 2-18 years). Current age, age at first abnormal DMSA scan, moderate-to-severe trabeculated bladder on US and/or VCUG, and VUR history were independent risk factors for development of CKD stage 5 (OR 0.752; 95%; CI 0.658-0.859; p < 0.001; OR 1.187; 95% CI 1.031-1.367; p = 0.017; OR 10.031; 95% CI 2.210-45.544; p = 0.003; OR 2.722; 95% CI 1.215-6.102; p = 0.015, respectively). Only eight CKD stage 5 patients underwent surgery related to a hostile bladder between 1 and 15 years old.Conclusion MMC-related CKD is common in childhood in Turkey. A proactive approach to neurogenic bladder management and early protective surgery in selected cases where conservative treatment has failed should be implemented to prevent progressive kidney failure in the pediatric MMC population in our country.
dc.identifier.doi10.1007/s00467-023-06212-5
dc.identifier.endpage1519
dc.identifier.issn0931-041X
dc.identifier.issn1432-198X
dc.identifier.issue5
dc.identifier.pmid38040872
dc.identifier.scopus2-s2.0-85178420777
dc.identifier.scopusqualityQ1
dc.identifier.startpage1509
dc.identifier.urihttps://doi.org/10.1007/s00467-023-06212-5
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5514
dc.identifier.volume39
dc.identifier.wosWOS:001112566400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofPediatric Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectChild
dc.subjectMyelomeningocele
dc.subjectNeurogenic bladder
dc.subjectPredictors
dc.subjectChronic kidney disease
dc.titleCharacteristics and predictors of chronic kidney disease in children with myelomeningocele: a nationwide cohort study
dc.typeArticle

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