Investigation of oxidant-antioxidant status in patients treated with hirudotherapy: an experimental study

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dc.contributor.authorSarikan, Ismail
dc.contributor.authorSavas, Hasan Basri
dc.date.accessioned2026-01-24T12:26:44Z
dc.date.available2026-01-24T12:26:44Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObjective: To examine the influence of hirudotherapy on parameters of oxidative stress. Method: The cross-sectional study was conducted from March 29 to September 29, 2021, at the Alanya Research and Training Hospital's Traditional and Complementary Medicine Application Centre, Turkey, and comprised adult volunteers of either gender. The participants were subjected to two sessions of hirudotherapy 4 weeks apart. Total antioxidant status, total oxidant status, oxidative stress index values, ischaemia-modified albumin level, paraoxonase 1, disulfide, native thiol, total thiol, and arylesterase levels were assessed at baseline and after the second hirudotherapy session. Data was analysed using SPSS 15. Results: Of the 50 subjects, 30(60%) were females and 20(40%) were males. The overall mean age was 47.10 +/- 15.16 years. Oxidative stress, ischaemia-modified albumin and disulfide levels decreased, but not significantly (p>0.05). The reduction in disulfide levels was significant (p=0.021). Conclusion: Hirudotherapy, within its limitations, could reduce oxidative stress.
dc.description.sponsorshipAlanya Alaaddin Keykubat University (Alkue) Scientific Research Projects Coordination Unit [2021-04-02-MAP10]
dc.description.sponsorshipAlanya Alaaddin Keykubat University (Alkue) Scientific Research Projects Coordination Unit (Project Number: 2021-04-02-MAP10) .
dc.identifier.doi10.47391/JPMA.9213
dc.identifier.endpage651
dc.identifier.issn0030-9982
dc.identifier.issue4
dc.identifier.pmid38751255
dc.identifier.scopus2-s2.0-85189069823
dc.identifier.scopusqualityQ3
dc.identifier.startpage647
dc.identifier.urihttps://doi.org/10.47391/JPMA.9213
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4872
dc.identifier.volume74
dc.identifier.wosWOS:001222498700009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPakistan Medical Assoc
dc.relation.ispartofJournal of The Pakistan Medical Association
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectAntioxidant activity
dc.subjectOxidative stress
dc.subjectMedicinal leeches
dc.subjectHirudin
dc.titleInvestigation of oxidant-antioxidant status in patients treated with hirudotherapy: an experimental study
dc.typeArticle

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