The impact of prophylactic lacosamide on LPS-induced neuroinflammation in aged rats

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dc.contributor.authorSavran, Mehtap
dc.contributor.authorÖzmen, Özlem
dc.contributor.authorErzurumlu, Yalçın
dc.contributor.authorSavaş, Hasri Basri
dc.contributor.authorAşçı, S.
dc.contributor.authorKaynak, M.
dc.date.accessioned2021-02-19T21:16:33Z
dc.date.available2021-02-19T21:16:33Z
dc.date.issued2019
dc.departmentALKÜ
dc.description.abstractSepsis-induced central nervous system damage is called sepsis-associated encephalopathy (SAE). In addition to neuroinflammation, oxidative stress and apoptosis act in the development of SAE. In the current study, we evaluated the protective effects of lacosamide (LCM) on neuroinflammation induced by lipopolysaccharide (LPS). Twenty-four Wistar albino rats were divided into 3 groups as controls, LPS group (5 mg/kg i.p.), and LPS plus LCM group (5 mg/kg i.p and 40 mg/kg i.p, respectively). In the rat brain, LPS-induced tissue damage was revealed histopathologically as hyperemia and microhemorrhages. LCM pretreatment ameliorated these histopathological changes. LPS decreased brain TAS levels and significantly increased MDA, CRP, HSP, IL-1 beta, and TNF-alpha expressions in the cortex, hippocampus, and cerebellum. Western analysis revealed increased brain tissue levels of TNF-alpha, NF-K beta, and caspase-3 following LPS. Prophylactic LCM treatment reversed these parameters including oxidative stress, inflammation, and apoptosis in the cortex, hippocampus, and cerebellum.
dc.identifier.doi10.1007/s10753-019-01053-7
dc.identifier.endpage1924en_US
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue5en_US
dc.identifier.pmid31267274
dc.identifier.scopusqualityQ1
dc.identifier.startpage1913en_US
dc.identifier.urihttps://doi.org/10.1007/s10753-019-01053-7
dc.identifier.urihttps://hdl.handle.net/20.500.12868/470
dc.identifier.volume42en_US
dc.identifier.wosWOS:000483660100036
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofInflammation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLPS
dc.subjectlacosamide
dc.subjectsepsis
dc.subjectoxidative stress
dc.subjectneuroinflammation
dc.subjectbrain
dc.titleThe impact of prophylactic lacosamide on LPS-induced neuroinflammation in aged rats
dc.typeArticle

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