Novel inflammatory targets for immunotherapies in pediatric patients with trichotillomania

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dc.contributor.authorKütük, Meryem Özlem
dc.contributor.authorTufan, Ali Evren
dc.contributor.authorKılıçaslan, Fethiye
dc.contributor.authorMutluer, Tuba
dc.contributor.authorGökçen, Cem
dc.contributor.authorKaradağ, Mehmet
dc.contributor.authorKütük, Özgür
dc.date.accessioned2021-02-19T21:16:43Z
dc.date.available2021-02-19T21:16:43Z
dc.date.issued2020
dc.departmentALKÜ
dc.descriptionKUTUK, OZGUR/0000-0001-9854-7220; Kandemir, Hasan/0000-0002-1138-4973; Tufan, Evren/0000-0001-5207-6240; Topal, Zehra/0000-0001-8397-5636
dc.description.abstractImmune dysregulation may be important in the etiology of obsessive-compulsive and related disordersandbody-focusedrepetitivebehaviors, such as Trichotillomania (TTM). The role of inflammation and inflammatory markers in TTM has received relatively little attention. This study was aimed to determine the expression levels of inflammatory markers (i.e. IL-1 beta, IL-1 alpha, IL-4, IL-6, IL-17, TNF-alpha and TGF-5) in peripheral blood mononuclear cells of children with TTM and healthy controls and to evaluate their association with clinical variables. Seventy-seven patients with TTM and 107 healthy controls were enrolled in the study. Peripheral blood was collected in standardized conditions. The mean age of patients and controls did not differ significantly (10.8 +/- 4.4 and 12.0 +/- 3.2 years; respectively). The majority of patients with TTM and controls were females (n = 55, 71.4 % and n = 55, 51.4 %; respectively); with a greater preponderance of females among TTM. Patients with TTM had significantly elevated expression levels of TNF-alpha, IL-6 and IL-17 compared to controls. However, the expression level of IL-4 was significantly reduced in TTM patients compared to controls. Accordingly, we found a proinflammatory state in TTM and those findings may suggest novel treatment options for TTM and further, crossdisciplinary studies focusing on neuro- inflammation in TTM conducted on larger samples are needed.
dc.description.sponsorshipScience Academy BAGEP program
dc.description.sponsorshipOzgur Kutuk acknowledges support from the Science Academy BAGEP program.
dc.identifier.doi10.1016/j.imbio.2020.151913
dc.identifier.issn0171-2985
dc.identifier.issue3en_US
dc.identifier.pmid32113788
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.imbio.2020.151913
dc.identifier.urihttps://hdl.handle.net/20.500.12868/531
dc.identifier.volume225en_US
dc.identifier.wosWOS:000539280500032
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherElsevier Gmbh
dc.relation.ispartofImmunobiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTrichotillomania
dc.subjectCytokines
dc.subjectImmune system
dc.subjectInflammation
dc.subjectObsessive-compulsive and related disorders
dc.titleNovel inflammatory targets for immunotherapies in pediatric patients with trichotillomania
dc.typeArticle

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