The effects of maternal body weight on iodine concentration in breast milk and cord blood and infant growth

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dc.authorid0000-0003-1233-246X
dc.authorid0000-0001-8759-4507
dc.authorid0000-0002-6394-8101
dc.contributor.authorKahraman, Ceren Sarahman
dc.contributor.authorSavas, Hasan Basri
dc.contributor.authorErdem, Dilek
dc.contributor.authorAyhan, Nurcan Yabanci
dc.date.accessioned2026-01-24T12:31:20Z
dc.date.available2026-01-24T12:31:20Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractBreast milk (BM) is the only source of iodine and bioactive compounds that influence growth and development in infants. The content of BM may be influenced by maternal body mass index (BMI). The aim of this study was to investigate the effect of maternal weight on BM and cord blood iodine concentrations, growth-related hormones, infant anthropometric measurements. A total of 84 mother-infant pairs participated. Levels of leptin, adiponectin and insulin-like growth factor-I (IGF-I) in postnatal BM and cord blood were analysed by enzyme-linked immunosorbent assay (ELISA), iodine by Sandell-Kolthoff reaction. Dietary iodine intake of women was determined by food frequency questionnaire, and anthropometric measurements of infants at birth and 3 months were evaluated. Dietary iodine intake was found to be similar in normal weight (NW) and overweight/obese (OW/OB) women (p > 0.05). Breast milk iodine concentration (BMIC) was 17.4 mu g in NW, 18.2 mu g in OB/OW women. Adiponectin in cord blood and IGF-I in BM were higher OB/OW than NW women (p < 0.05). Positive correlations were found between the infant birth weight and adiponectin in BM, between the infant body weight at 3 months and leptin and adiponectin in BM, between the infant birth head circumference and IGF-I in BM (p < 0.05). In multiple linear regression model, leptin and adiponectin in BM had a positive effect on infant body weight (p < 0.05). Maternal BMI may influence infant body weight via leptin and adiponectin in BM and infant head circumference via IGF-I. No relationship was found between maternal BMI and iodine levels and anthropometric measurements of the infant. Longitudinal studies are recommended to understand the effect of BMIC on growth.
dc.description.sponsorshipAlanya Alaaddin Keykubat University Scientific Research Projects [2022-04-03-MAP05]
dc.description.sponsorshipThis study was supported by Alanya Alaaddin Keykubat University Scientific Research Projects coordinatorship with the project number 2022-04-03-MAP05.
dc.identifier.doi10.1017/S2040174425000017
dc.identifier.issn2040-1744
dc.identifier.issn2040-1752
dc.identifier.pmid39882715
dc.identifier.scopus2-s2.0-85217623463
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1017/S2040174425000017
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5818
dc.identifier.volume16
dc.identifier.wosWOS:001410972500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCambridge Univ Press
dc.relation.ispartofJournal of Developmental Origins of Health and Disease
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectBreast milk
dc.subjectIodine
dc.subjectLeptin
dc.subjectAdiponectin
dc.subjectMaternal weight
dc.subjectInfant growth
dc.titleThe effects of maternal body weight on iodine concentration in breast milk and cord blood and infant growth
dc.typeArticle

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