Pediatric Mycosis Fungoides: Retrospective Analysis of a Series With CD8+ Profile and Female Predominance

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dc.contributor.authorPurnak, Seda
dc.contributor.authorMark, Lawrence A.
dc.date.accessioned2026-01-24T12:29:00Z
dc.date.available2026-01-24T12:29:00Z
dc.date.issued2022
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractBackground: Mycosis fungoides (MF) in children is a rare disease and there are limited data regarding the behavior of the disease in this age group. We aimed to collect additional data to better understand the clinicopathologic features of MF in children. Materials and Methods: This study was a retrospective analysis of pediatric MF patients (diagnosed at age 0 to 18 y). Results: Thirteen pediatric patients with MF were identified. Female predominance was observed with a ratio of 1.6:1. Median values for age of onset of skin lesions and age at the time of histologic diagnosis were 5 and 12 years, respectively. All patients had early stage (stage IA to IIA) of MF at the time of diagnosis. Hypopigmented MF comprised 77% of all study patients, followed by classic MF (15%) and pagetoid reticulosis (8%). The lower extremity (especially proximal leg) followed by trunk and upper extremity were most commonly affected sites. Seven of 9 patients who had available immunohistochemistry data showed CD8(+) predominance. Five of 8 patients whose follow-up data was available, achieved complete response with narrowband ultraviolet B treatment, while 2 and 1 had near complete response and partial response, respectively. Conclusions: Our study demonstrated female sex and CD8(+) profile predominance. Hypopigmented MF constituted the majority of cases. We observed good responses with narrowband ultraviolet B treatment.
dc.description.sponsorshipTUBITAK, Ankara, Turkey
dc.description.sponsorshipS.P. was a recipient of TUBITAK scholarship (2015-2016), Ankara, Turkey. The other author declares no conflict of interest.
dc.identifier.doi10.1097/MPH.0000000000002354
dc.identifier.endpageE998
dc.identifier.issn1077-4114
dc.identifier.issn1536-3678
dc.identifier.issue7
dc.identifier.pmid34699461
dc.identifier.scopus2-s2.0-85119072073
dc.identifier.scopusqualityQ3
dc.identifier.startpageE994
dc.identifier.urihttps://doi.org/10.1097/MPH.0000000000002354
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5049
dc.identifier.volume44
dc.identifier.wosWOS:000860862800023
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal of Pediatric Hematology Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectcutaneous T-cell lymphoma
dc.subjectmycosis fungoides
dc.subjectchildren
dc.subjectphototherapy
dc.titlePediatric Mycosis Fungoides: Retrospective Analysis of a Series With CD8+ Profile and Female Predominance
dc.typeArticle

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