Multicenter evaluation of ambulatory blood pressure in children with CAKUT: distinctive profiles in the cystic dysplasia subgroup

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dc.authorid0000-0002-0995-8501
dc.authorid0000-0002-1324-232X
dc.authorid0000-0003-0645-8170
dc.contributor.authorYel, Sibel
dc.contributor.authorGunay, Neslihan
dc.contributor.authorYildirim, Pelin Abdal
dc.contributor.authorDemir, Belde Kasap
dc.contributor.authorSoyaltin, Eren
dc.contributor.authorKara, Aslihan
dc.contributor.authorGurgoze, Metin Kaya
dc.date.accessioned2026-01-24T12:30:54Z
dc.date.available2026-01-24T12:30:54Z
dc.date.issued2026
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractBackground Hypertension (HT) is an important risk factor in patients with congenital anomalies of the kidney and urinary tract (CAKUT), independent of the existing anomaly in childhood. This study aimed to investigate masked hypertension and/or blood pressure profiles in different subgroups with a normal glomerular filtration rate (GFR). Methods The study included participants from seven different pediatric nephrology centers in T & uuml;rkiye. Ambulatory blood pressure monitoring (ABPM) was performed on patients aged 5-18 years, diagnosed with CAKUT, with a GFR above 100 ml/min/m(2), and normal office blood pressure measurements. Validated Mobil-O-Graph or Spacelabs devices were used in all centers. Results In total, 118 healthy control data and 322 patients with CAKUT were evaluated, consisting of 73 (22.7%) with agenesis, 79 (24.5%) with cystic dysplasia, 92 (28.6%) with vesicoureteral reflux, 18 (5.6%) with UPJ (ureteropelvic junction) obstruction, and 60 (18.6%) with other conditions. In all CAKUT patients, daytime systolic blood pressure (SBP) and both day and nighttime diastolic blood pressure (DBP) loads were significantly higher compared to the healthy control group (p < 0.05). Nocturnal hypertension was identified in 58 (18%) of 322 children, whereas none of the control group presented hypertension. Children with cystic dysplasia had the highest nighttime hypertension proportions (22.7%) when compared to other subgroups. All data revealed higher total systolic-diastolic SDS and total mean SDS in the cystic dysplasia subgroup (p < 0.05). Conclusions The findings underscore the importance of blood pressure monitoring in the follow-up of patients with CAKUT, especially those with cystic dysplasia, even in the absence of GFR decline.
dc.identifier.doi10.1007/s00467-025-07001-y
dc.identifier.endpage464
dc.identifier.issn0931-041X
dc.identifier.issn1432-198X
dc.identifier.issue2
dc.identifier.pmid41077569
dc.identifier.scopus2-s2.0-105018599879
dc.identifier.scopusqualityQ1
dc.identifier.startpage457
dc.identifier.urihttps://doi.org/10.1007/s00467-025-07001-y
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5515
dc.identifier.volume41
dc.identifier.wosWOS:001591962800001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofPediatric Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectAmbulatory blood pressure monitoring
dc.subjectCAKUT
dc.subjectChildren
dc.subjectMasked hypertension
dc.subjectCystic dysplasia
dc.titleMulticenter evaluation of ambulatory blood pressure in children with CAKUT: distinctive profiles in the cystic dysplasia subgroup
dc.typeArticle

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