B cell depletion in patients with rheumatoid arthritis is associated with reduced IL-1? in GCF

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dc.authorid0000-0003-2246-8782
dc.contributor.authorHatipoglu, Mukerrem
dc.contributor.authorDaltaban, Ozlem
dc.contributor.authorUgur, Sevcan
dc.contributor.authorUstun, Kemal
dc.contributor.authorKacar, Cahit
dc.contributor.authorTuncer, Tiraje
dc.contributor.authorKantarci, Alpdogan
dc.date.accessioned2026-01-24T12:30:54Z
dc.date.available2026-01-24T12:30:54Z
dc.date.issued2022
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObjectives We evaluated the effect of B cell depletion on the clinical periodontal findings and IL-1 beta and MMP-8 levels of the gingival crevicular (GCF) fluid in patients with rheumatoid arthritis (RA). Materials and methods Seventy patients were included in this case-control study. Twenty patients with RA were undergoing B-cell depletion treatment. The second group of RA patients (n= 20) were undergoing non-B-cell depletion treatment with Disease-Modifying Anti-Rheumatic Drugs (DMARD). Control group, with no RA, consisted of 30 individuals. Periodontal parameters including probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), gingival index (GI), and plaque index (PI) were recorded. IL-1 beta and MMP-8 levels in GCF were determined using enzyme-linked immunosorbent assay. Rheumatological parameters including Disease Activity Score-28 (DAS-28), rheumatoid factor levels (RF), and anti-cyclic citrullinated peptide levels were included in the data analyses. Results All groups were similar in PD, CAL, BOP, GI, and PI measures. GCF IL-1 beta levels were 1.85 +/- 1.67 pg in the B-cell depletion group, 10.50 +/- 13.16 pg in the DMARD group, and 34.12 +/- 29.45 pg in the control group (p < 0.001). MMP-8 levels were 21.00 +/- 4.23 pg in the B-cell depletion group, 8.16 +/- 6.94 pg in the DMARD group, and 21.45 +/- 8.67 pg in the control group (p < 0.001). DAS 28, RF, and anti-CCP were similar in RA groups. Conclusions GCF IL-1 beta levels were significantly lower in B cell depletion group, and MMP-8 levels were significantly lower in DMARD group, suggesting that rheumatoid arthritis treatments may modify biochemical parameters of GCF.
dc.description.sponsorshipAkdeniz University Scientific Projects Coordination Unit [TSA-2017-2431]
dc.description.sponsorshipThis study is funded by the Akdeniz University Scientific Projects Coordination Unit (TSA-2017-2431).
dc.identifier.doi10.1007/s00784-022-04378-0
dc.identifier.endpage4313
dc.identifier.issn1432-6981
dc.identifier.issn1436-3771
dc.identifier.issue6
dc.identifier.pmid35578115
dc.identifier.scopus2-s2.0-85130124404
dc.identifier.scopusqualityQ1
dc.identifier.startpage4307
dc.identifier.urihttps://doi.org/10.1007/s00784-022-04378-0
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5519
dc.identifier.volume26
dc.identifier.wosWOS:000796324400002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofClinical Oral Investigations
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectBiological therapy
dc.subjectGingival crevicular fluid
dc.subjectPeriodontitis
dc.subjectRheumatoid arthritis
dc.titleB cell depletion in patients with rheumatoid arthritis is associated with reduced IL-1? in GCF
dc.typeArticle

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