Epidemiology of hepatitis B, hepatitis C, and syphilis co-infections in HIV-1 patients: a retrospective cross-sectional study of prevalence and viral load correlates

Basit Öğe Kaydı
dc.authorid0000-0002-0663-1802
dc.contributor.authorAydogan, Sibel
dc.contributor.authorKirca, Fusun
dc.contributor.authorGozalan, Aysegul
dc.contributor.authorAslan, Ferhat Gurkan
dc.contributor.authorGurler, Merve
dc.contributor.authorToyran, Alparslan
dc.contributor.authorDinc, Bedia
dc.date.accessioned2026-01-24T12:26:44Z
dc.date.available2026-01-24T12:26:44Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractBACKGROUND: Co-infections with hepatitis B (HBV), hepatitis C (HCV) and syphilis complicate the clinical management of people living with HIV by influencing disease progression, treatment response, and transmission risk. Despite the growing HIV burden in T & uuml;rkiye, data on the impact of these coinfections remain limited. OBJECTIVES: To determine the prevalence of HBV, HCV, and syphilis coinfections in adults with HIV-1 and to examine their associations with demographics and HIV-1 viral load. DESIGN: Retrospective cross-sectional study SETTING: Single center, tertiary care hospital in T & uuml;rkiye PATIENTS AND METHODS: Adults diagnosed with HIV-1 between March 2019 and June 2024 at Ankara Bilkent City Hospital were included. Demographic information, HIV viral load measurements, and serological and molecular test results for HBV, HCV, and syphilis were retrieved from the institutional laboratory database. Coinfection status was assessed relative to age, gender, and HIV viral load. MAIN OUTCOME MEASURES: Prevalence and distribution of HBV, HCV, and syphilis coinfections and their associations with demographic variables and HIV viral load. SAMPLE SIZE: 724 patients RESULTS: The study population was predominantly male (86%), with a median age of 40 years. Syphilis was the most common coinfection (25.6%), followed by HBV at 4.1% and HCV at 1.8%. Syphilis was significantly more prevalent among men (P=.001), and HBV coinfection was associated with older age (P=.005). No significant associations were observed between HIV viral load and any co-infection. Notably, a substantial proportion of patients, especially those newly diagnosed after 2019, had high HIV RNA levels, suggesting delayed diagnosis and treatment initiation. Triple coinfections were rare but remain clinically relevant. CONCLUSIONS: The high prevalence of syphilis and delayed HIV diagnoses highlight the urgent need for improved screening protocols, timely initiation of antiretroviral therapy, and broader implementation of HBV vaccination programs. An integrated multisectoral approach is critical to address the overlapping clinical and public health burdens posed by these co-infections. Healthcare strategies must consider the impact of COVID-19-related service disruptions, which likely contributed to delays in diagnosis and treatment. LIMITATIONS: Lack of data on patients' behavioral risk factors and no follow-up on treatment outcomes for syphilis
dc.identifier.doi10.5144/0256-4947.2025.28.08.1204
dc.identifier.endpage352
dc.identifier.issn0256-4947
dc.identifier.issn1319-9226
dc.identifier.issue5
dc.identifier.pmid39962895
dc.identifier.scopus2-s2.0-105017893997
dc.identifier.scopusqualityQ2
dc.identifier.startpage345
dc.identifier.urihttps://doi.org/10.5144/0256-4947.2025.28.08.1204
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4886
dc.identifier.volume45
dc.identifier.wosWOS:001589356400006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherK Faisal Spec Hosp Res Centre
dc.relation.ispartofAnnals of Saudi Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectHIV
dc.subjectviral load
dc.subjectHBV
dc.subjectHCV
dc.subjectsyphilis
dc.subjectco-infections
dc.titleEpidemiology of hepatitis B, hepatitis C, and syphilis co-infections in HIV-1 patients: a retrospective cross-sectional study of prevalence and viral load correlates
dc.typeArticle

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