Are Platelet-related Parameters Predictive of the Prognosis of Hodgkin's Lymphoma?

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dc.authorid0000-0002-7195-1845
dc.authorid0000-0002-2835-6979
dc.authorid0000-0001-9178-2850
dc.contributor.authorAkdeniz, Aydan
dc.contributor.authorMehtap, Ozgur
dc.contributor.authorKarakus, Volkan
dc.contributor.authorUnal, Serkan
dc.contributor.authorAygun, Kemal
dc.contributor.authorTemel, Gulhan Orekici
dc.contributor.authorTombak, Anil
dc.date.accessioned2026-01-24T12:26:40Z
dc.date.available2026-01-24T12:26:40Z
dc.date.issued2021
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObjective: Hodgkin's lymphoma has a good prognosis unless it has relapsed or become refractory. The predictive value of platelet (Plt)-related parameters, namely, mean Plt volume (MPV), plateletcrit (PCT), Plt distribution width, and Plt, is shown in some solid tumors and hematological malignancies, but it remains unknown in Hodgkin's lymphoma. This study aimed to define their values and effects on staging and relapsing status in patients with Hodgkin's lymphoma by comparing them with those in healthy subjects. Methods: Values of Plt-related parameters of 217 patients with Hodgkin's lymphoma and 205 healthy individuals were documented and compared according to the disease stage and relapsing status. We defined the cutoff values for diagnosis, staging, and relapsing status of these parameters using the receiving operating characteristic curve analysis. Results: For diagnosis, the cutoff values of MPV, Plt, and PCT were 8.49 fL, 32,1000/mm(3), and 0.31, respectively. For staging, the cutoff values of MPV and Plt were 9.5 fL and 12 fL, respectively. None of the parameters were associated with relapsing status. Conclusion: This is the first study evaluating Plt-related parameters in Hodgkin's lymphoma. Further studies including survival analyses will clarify the effect of these parameters on Hodgkin's lymphoma.
dc.identifier.doi10.4274/BMJ.galenos.2021.35403
dc.identifier.endpage374
dc.identifier.issn1305-9319
dc.identifier.issn1305-9327
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85122440032
dc.identifier.scopusqualityQ4
dc.identifier.startpage367
dc.identifier.urihttps://doi.org/10.4274/BMJ.galenos.2021.35403
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4851
dc.identifier.volume17
dc.identifier.wosWOS:000735123100013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherGalenos Yayincilik
dc.relation.ispartofMedical Journal of Bakirkoy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectHodgkin's lymphoma
dc.subjectplatelet
dc.subjectMPV
dc.subjectPCT
dc.subjectPDW
dc.titleAre Platelet-related Parameters Predictive of the Prognosis of Hodgkin's Lymphoma?
dc.typeArticle

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