Telomerase activators from 20(27)-octanor-cycloastragenol via biotransformation by the fungal endophytes

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dc.contributor.authorDuman, Seda
dc.contributor.authorEkiz Dinçman, Güner
dc.contributor.authorYilmaz, Sinem
dc.contributor.authorYusufoğlu, Hasan Soliman
dc.contributor.authorBallar Kirmizibayrak, Petek
dc.contributor.authorBedir, Erdal
dc.date.accessioned2026-01-24T12:20:43Z
dc.date.available2026-01-24T12:20:43Z
dc.date.issued2021
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractCycloastragenol [20(R),24(S)-epoxy-3?,6?,16?,25-tetrahydroxycycloartane] (CA), the principle sapogenol of many cycloartane-type glycosides found in Astragalus genus, is currently the only natural product in the anti-aging market as telomerase activator. Here, we report biotransformation of 20(27)-octanor-cycloastragenol (1), a thermal degradation product of CA, using Astragalus species originated endophytic fungi, viz. Penicillium roseopurpureum, Alternaria eureka, Neosartorya hiratsukae and Camarosporium laburnicola. Fifteen new biotransformation products (2–16) were isolated, and their structures were established by NMR and HRESIMS. Endophytic fungi were found to be capable of performing hydroxylation, oxidation, ring cleavage-methyl migration, dehydrogenation and Baeyer-Villiger type oxidation reactions on the starting compound (1), which would be difficult to achieve by conventional synthetic methods. In addition, the ability of the metabolites to increase telomerase activation in Hekn cells was evaluated, which showed from 1.08 to 12.4-fold activation compared to the control cells treated with DMSO. Among the compounds tested, 10, 11 and 12 were found to be the most potent in terms of telomerase activation with 12.40-, 7.89- and 5.43-fold increase, respectively (at 0.1, 2 and 10 nM concentrations, respectively). © 2021 Elsevier Inc.
dc.description.sponsorship(114Z958); Prince Sattam bin Abdulaziz University, PSAU; Türkiye Bilimsel ve Teknolojik Araştirma Kurumu, TÜBITAK
dc.identifier.doi10.1016/j.bioorg.2021.104708
dc.identifier.issn0045-2068
dc.identifier.pmid33621779
dc.identifier.scopus2-s2.0-85101170744
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.bioorg.2021.104708
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4525
dc.identifier.volume109
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Inc.
dc.relation.ispartofBioorganic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20260121
dc.subjectCycloastragenol
dc.subjectEndophytic fungi
dc.subjectFungal biotransformation
dc.subjectPotent metabolites
dc.subjectSaponins
dc.subjectTelomerase activation
dc.titleTelomerase activators from 20(27)-octanor-cycloastragenol via biotransformation by the fungal endophytes
dc.typeArticle

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