Quantitative evaluation of brain volumes in drug-free major depressive disorder using MRI-Cloud method

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dc.authorid0000-0002-2306-5937
dc.contributor.authorAvnioglu, Seda
dc.contributor.authorVelioglu, Halil Aziz
dc.contributor.authorCankaya, Seyda
dc.contributor.authorYulug, Burak
dc.date.accessioned2026-01-24T12:29:00Z
dc.date.available2026-01-24T12:29:00Z
dc.date.issued2021
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractBackground Quantitative analysis of the high-resolution T1-weighted images provides useful markers to measure anatomical changes during brain degeneration related to major depressive disorder (MDD). However, there are controversial findings regarding these volume alterations in MDD indicating even to increased volumes in some specific regions in MDD patients. Methods This study is a case-controlled study including 23 depression patients and 15 healthy subject person and 20-38 years of age, who have been treated at the Neurology and Psychiatry Department here. We compared specific anatomic regions between drug-free MDD patients and control group through MRI-Cloud, which is a novel brain imaging method that enables to analyze multiple brain regions simultaneously. Results We have found that frontal, temporal, and parietal hemispheric volumes and middle frontal gyrus, inferior frontal gyrus, superior parietal gyrus, cingulum-hippocampus, lateral fronto-orbital gyrus, superior temporal gyrus, superior temporal white matter, middle temporal gyrus subanatomic regions were significantly reduced bilaterally in MDD patients compared to the control group, while striatum, amygdala, putamen, and nucleus accumbens bilaterally increased in MDD group compared to the control group suggesting that besides the heterogeneity among studies, also comorbid factors such as anxiety and different personal traits could be responsible for these discrepant results. Conclusion Our study gives a strong message that depression is associated with altered structural brain volumes, especially, in drug-free and first-episode MDD patients who present with similar duration and severity of depression while the role of demographic and comorbid risk factors should not be neglected.
dc.description.sponsorshipAlanya Alaaddin Keykubat University Faculty of Medicine Ethics Committee [2020/25-20]
dc.description.sponsorshipEthical approval: All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This retrospective study was conducted after the approval of Alanya Alaaddin Keykubat University Faculty of Medicine Ethics Committee (2020/25-20).
dc.identifier.doi10.1097/WNR.0000000000001682
dc.identifier.endpage1034
dc.identifier.issn0959-4965
dc.identifier.issn1473-558X
dc.identifier.issue12
dc.identifier.pmid34075004
dc.identifier.startpage1027
dc.identifier.urihttps://doi.org/10.1097/WNR.0000000000001682
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5054
dc.identifier.volume32
dc.identifier.wosWOS:000674716500009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofNeuroreport
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectbrain volume
dc.subjectdepression (major depressive disorder)
dc.subjectMRI-Cloud
dc.titleQuantitative evaluation of brain volumes in drug-free major depressive disorder using MRI-Cloud method
dc.typeArticle

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