Topological network mechanisms of clinical response to antidepressant treatment in drug-naive major depressive disorder

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dc.contributor.authorUykur, Abdullah Burak
dc.contributor.authorYıldız, Sultan
dc.contributor.authorVelioğlu, Halil Aziz
dc.contributor.authorÖzşimşek, Ahmet
dc.contributor.authorÖktem, Ece Özdemir
dc.contributor.authorBayraktaroğlu, Zübeyir
dc.contributor.authorErgün, Tarkan
dc.contributor.authorLakadamyalı, Hatice
dc.contributor.authorHanoğlu, Lütfi
dc.contributor.authorHanoğlu, Lütfi
dc.contributor.authorÇankaya, Şeyda
dc.contributor.authorSaatçi, Özlem
dc.contributor.authorYuluğ, Burak
dc.date.accessioned2021-02-19T21:20:50Z
dc.date.available2021-02-19T21:20:50Z
dc.date.issued2021
dc.departmentALKÜ
dc.description.abstractAim: There is rapidly increasing evidence that remission of MDD is associated with substantial changes in functional brain connectivity. These New data have provided a holistic view on the mechanism of antidepressants on multiple levels that goes beyond their conventional effects on neurotransmitters. Method: The study was approved by the Local Ethics Committee of Istanbul Medipol University (10840098-604.01.01-E.65129) and followed the Helsinki Declaration principles. In our study, we have evaluated the effect of six weeks of treatment with antidepressants (escitalopram and duloxetine), and tested the underlying brain functional connectivity through a Graph analysis approach in a well-defined first-episode, drug-naive, and non-comorbid population with MDD. Results: Beyond indicating that there was a significant correlation between the antidepressant response and topological characteristics of the brain, our results suggested that global rather than regional network alterations may be implicated in the antidepressant effect. Conclusion: Despite the small-sample size and non-controlled study design, our study provides important and relevant clinical data regarding the underlying mechanisms of the antidepressants on topological dynamics in the human brain. © 2020 Elsevier Ltd
dc.identifier.doi10.1016/j.jocn.2020.12.001
dc.identifier.endpage90en_US
dc.identifier.issn0967-5868
dc.identifier.pmid33358344
dc.identifier.scopusqualityQ1
dc.identifier.startpage82en_US
dc.identifier.urihttps://doi.org/10.1016/j.jocn.2020.12.001
dc.identifier.urihttps://hdl.handle.net/20.500.12868/720
dc.identifier.volume84en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherChurchill Livingstone
dc.relation.ispartofJournal of Clinical Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDuloxetine
dc.subjectEscitalopram
dc.subjectfMRI
dc.subjectGraph analysis
dc.subjectMajor depressive disorder
dc.titleTopological network mechanisms of clinical response to antidepressant treatment in drug-naive major depressive disorder
dc.typeArticle

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