The effects of mesenchymal stem cells applied during the subacute period in peripheral neuropathy

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dc.authorid0000-0003-3585-2599
dc.authorid0000-0003-3182-2122
dc.authorid0000-0003-0334-8152
dc.authorid0000-0001-5284-7439
dc.contributor.authorKiroglu, Olcay
dc.contributor.authorMaytalman, Erkan
dc.contributor.authorAlizade, Ares
dc.contributor.authorEmre, Mustafa
dc.contributor.authorZorludemir, Suzan
dc.contributor.authorAksu, Fazilet
dc.date.accessioned2026-01-24T12:29:18Z
dc.date.available2026-01-24T12:29:18Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractPurpose: The study aims to investigate the effect of bone marrow-derived mesenchymal stem cells (BM-MSCs) administered subacute period to neuropathic mice on allodynia and nerve-muscle tissue functions during 24 weeks. Materials and Methods: Peripheral neuropathy was induced by partial sciatic nerve ligation. Experiments were conducted in Control, Sham, Neuropathic, BM-MSC, and Neuropathic+BM-MSC groups. Allodynia was measured by cold plate test at the 2nd, nd , 6th, th , and 24th th weeks. Electrophysiological and histopathological examinations were performed on isolated nerve-muscle tissues at the end of the 24th th week. Results: Allodynia threshold increased in the Neuropathic+BM-MSC group (7.76 +/- 0.33 sec) from the 6 th week and continued to increase along 24 weeks compared to the Neuropathic group (4.36 +/- 0.21 sec). Action potential (137.9 +/- 7.85 mV) and depolarization (0.74 +/- 0.01 msec) values of the Neuropathic+BM-MSC group exhibited partial improvement compared to the Neuropathic group (121.5 +/- 3.03 mV and 0.81 +/- 0.02 msec, respectively) at the 24th th week. Muscle tissue's resting membrane potential values increased in the Neuropathic+BM-MSC group compared to the Neuropathic group (-73.4 +/- 0.2 and-87.7 +/- 0.2 mV, respectively). Histopathological examination of nerve tissue revealed loss of myelinated axons and significant fibrosis in the endoneurium in the Neuropathic group while Schwann cell proliferation and preservation of myelinated axons were observed in the Neuropathic+BMMSC group. Muscle fiber atrophy, compensatory hypertrophic fibers, and increased central nuclei were seen in the Neuropathic group, while small atrophic muscle fiber groups were identified in the Neuropathic+BM-MSC group. Conclusion: BM-MSC application in the subacute period is found to reduce allodynia and provide functional recovery in nerve-muscle tissue in experimental peripheral neuropathy.
dc.description.sponsorshipAcknowledgement: We would like to thank Berk Celikyurek and Semih ustun for editing contributions.
dc.identifier.doi10.17826/cumj.1453906
dc.identifier.endpage438
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue2
dc.identifier.startpage424
dc.identifier.trdizinid1248690
dc.identifier.urihttps://doi.org/10.17826/cumj.1453906
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1248690
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5261
dc.identifier.volume49
dc.identifier.wosWOS:001276925000004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherCukurova Univ, Fac Medicine
dc.relation.ispartofCukurova Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subject. . Mesenchymal stem cell
dc.subjectperipheral neuropathy
dc.subjectpain
dc.titleThe effects of mesenchymal stem cells applied during the subacute period in peripheral neuropathy
dc.typeArticle

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