Thiolated layered double hydroxide-based nanoparticles: A study on mucoadhesiveness and cytotoxicity

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dc.authorid0000-0003-3161-1042
dc.authorid0000-0002-9127-2380
dc.contributor.authorSenturk, Sema
dc.contributor.authorKaplan, Ozlem
dc.contributor.authorBal, Kevser
dc.contributor.authorTopcu, Kubra Sen Bas
dc.contributor.authorGok, Mehmet Koray
dc.date.accessioned2026-01-24T12:31:07Z
dc.date.available2026-01-24T12:31:07Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractThe aim of this study was the synthesis and characterization of thiolated Mg/Al Layered double hydroxide nanoparticles (nLDH) that can adhere to mucosal surfaces. For this purpose, initially, nLDH were synthesized and then their surface was modified with L-cysteine (Cys). Then the Cys-modified nanoparticle structure (nLDHCys) Cys ) was characterized by FTIR, XRD and FE-SEM/EDS, and the amount of thiol groups was determined using the iodometric method. The cytotoxicity properties of nLDH and LDHCys Cys were examined on cervical (HeLa), fibroblast (L929) and colon (HT29) cell lines. In addition, the adhesion of nanoparticles to mucosal surfaces has been evaluated through mucin interaction experiments and ex vivo tests on ewe vaginal tissue. The results from characterization studies prove that Cys molecule has been successfully modified on the surface of nLDH. Cytotoxicity studies demonstrated that Cys modification did not negatively affect the cell viability, and these results were extremely close to those of nLDH. Ex vivo tests on ewe vaginal tissue and mucin interaction demonstrated that nLDHCys Cys enhanced retention on the mucosal surface. Considering their retention ability to mucosal surface and their biocompatible nature, nLDHCys Cys is expected to play an important role as a promising option for a safe mucoadhesive nanoparticle system for biological applications in the future.
dc.description.sponsorshipPresidency of Turkey, Presidency of Strategy and Budget [DPT-2019K12-149071]
dc.description.sponsorshipThis research supported with DPT-2019K12-149071 project by Presidency of Turkey, Presidency of Strategy and Budget.
dc.identifier.doi10.1016/j.colsurfa.2024.135461
dc.identifier.issn0927-7757
dc.identifier.issn1873-4359
dc.identifier.scopus2-s2.0-85205341272
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.colsurfa.2024.135461
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5662
dc.identifier.volume704
dc.identifier.wosWOS:001334339400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofColloids and Surfaces A-Physicochemical and Engineering Aspects
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectMucoadhesion
dc.subjectThiolation
dc.subjectThiolated LDH nanoparticles
dc.subjectSurface modification of LDH
dc.titleThiolated layered double hydroxide-based nanoparticles: A study on mucoadhesiveness and cytotoxicity
dc.typeArticle

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