Evaluation of the effect of a novel ?3-adrenergic agonist on choroidal vascularity

dc.contributor.authorTopçuoğlu, Murat
dc.contributor.authorAslan, Fatih
dc.date.accessioned2023-11-30T06:53:55Z
dc.date.available2023-11-30T06:53:55Z
dc.date.issued2021
dc.departmentALKÜ, Fakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractPURPOSE. To determine the effect of the new ?3-agonist (mirabegron), which is used for overactive bladder (OAB) treatment, on central retinal thickness (CRT) and choroidal vascularity. MATERIAL AND METHODS. The 26 eyes of 26 cases using 50 mg tablet mirabegron once per day for OAB were included in this prospective case control study. The CRT, choroidal thickness (ChT), and choroidal vascularity were measured at baseline, week 1 (W1), month 1 (M1), month 2 (M2), and month 3 (M3). Subfoveal ChT measurement included the total subfoveal choroidal thickness (SFCT), and the small and large choroidal vessel layer (SCVL and LCVL) thickness. The total choroidal area (TCA), lumen area (LA), stromal area (SA), stroma/lumen ratio, and choroidal vascularity index (CVI) were measured with the Image-J software. RESULTS. The largest SFCT increase compared to baseline was at M1 (26.8 ± 40.8 ?m, P = 0.001). The subfoveal SCVL thickness showed a significant decrease at M2 and M3 (?6.0 ± 8.9 ?m, P = 0.002; ?7.8 ± 13.4 ?m, P = 0.046, respectively). LCVL thickness showed a significant increase at W1, M1, and M2, with the largest at M1. CVI showed a significant increase at M1, M2, and M3 (P < 0.05 for all). The TCA, LA, and SA showed a significant increasing trend at all follow-up periods. LA/SA decreased at W1 because of stromal expansion but increased at M3 with more prominent vascular dilatation. CRT values showed no significant change. CONCLUSIONS. Mirabegron had a significant effect on choroidal thickness. Choroidal vascular response is in the form of narrowing in the choriocapillaris and enlargement in the Haller's layer.
dc.identifier.doi10.1167/iovs.62.9.17
dc.identifier.issue9en_US
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85110335996&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=20c4fe371b9b908d4f7e419f791331ff&sot=aff&sdt=cl&cluster=scofreetoread%2c%22all%22%2ct&sl=72&s=AF-ID%28%22Alanya+Alaaddin+Keykubat+University%22+60198720%29+AND+SUBJAREA%28MEDI%29&relpos=106&citeCnt=4&searchTerm=
dc.identifier.urihttps://hdl.handle.net/20.500.12868/2439
dc.identifier.urihttps://iovs.arvojournals.org/article.aspx?articleid=2776450
dc.identifier.volume62en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofInvestigative Ophthalmology and Visual Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBladder overactivity
dc.subjectChoroid
dc.subjectChoroidal vascularity index
dc.subjectMirabegron
dc.subjectOCT
dc.subjectRetina
dc.subject?3-adrenoceptor agonist
dc.titleEvaluation of the effect of a novel ?3-adrenergic agonist on choroidal vascularity
dc.typeArticle

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