2D:4D ratio, alexithymia, impulsivity, aggression, and ADHD in men with opioid and methamphetamine use disorders: A comparative analysis with healthy controls

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dc.contributor.authorAkkuş, Merve
dc.contributor.authorAydoğan Avşar, Pınar
dc.date.accessioned2026-01-24T12:20:43Z
dc.date.available2026-01-24T12:20:43Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractSubstance use disorder is an important mental health problem with increasing frequency. This study aims to investigate the 2D:4D ratio, Dr-I values (right-left differences), alexithymia, aggression, impulsivity, and attention deficit hyperactivity disorder (ADHD) symptoms in male patients with methamphetamine use disorder (MUD), opioid use disorder (OUD), and healthy controls. The study included a total of 57 male patients diagnosed with OUD, 42 male patients diagnosed with MUD, and 72 healthy male controls. The study indicated that the OUD and MUD patients were significantly different from the healthy controls in terms of the 2D:4D ratio, alexithymia, impulsivity, aggression, and ADHD. Compared to healthy controls, 2D:4D ratios, and Dr-I values were lower in OUD and MUD patients. OUD and MUD patients had higher scores of alexithymia, impulsivity, aggression, and ADHD compared to healthy controls. There were statistically significant negative correlations between the right-hand 2D:4D ratios and the ADHD, impulsivity, alexithymia and aggression scores and a significant negative correlation between Dr-I scores and the impulsivity scores of MUD and OUD patients. These findings contribute to the existing literature examining the complex relationship between prenatal testosterone exposure, substance use disorders and related psychological traits. © 2024 Elsevier B.V.
dc.identifier.doi10.1016/j.earlhumdev.2024.105946
dc.identifier.issn0378-3782
dc.identifier.pmid38280313
dc.identifier.scopus2-s2.0-85183478263
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.earlhumdev.2024.105946
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4538
dc.identifier.volume189
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofEarly Human Development
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20260121
dc.subjectADHD
dc.subjectAlexithymia
dc.subjectImpulsivity
dc.subjectMethamphetamine
dc.subjectOpioid
dc.title2D:4D ratio, alexithymia, impulsivity, aggression, and ADHD in men with opioid and methamphetamine use disorders: A comparative analysis with healthy controls
dc.typeArticle

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