Determination of carcinoembryonic antigen (CEA) by surface plasmon resonance-enhanced total internal reflection ellipsometry (SPRe-TIRE)

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dc.authorid0000-0003-1676-2870
dc.authorid0000-0002-5550-106X
dc.authorid0000-0003-4702-7457
dc.authorid0000-0002-0568-4283
dc.contributor.authorErkal-Aytemur, Asli
dc.contributor.authorSahin, Samet
dc.contributor.authorUstundag, Zafer
dc.contributor.authorMulazimoglu, Ibrahim Ender
dc.contributor.authorCaglayan, Mustafa Oguzhan
dc.date.accessioned2026-01-24T12:31:27Z
dc.date.available2026-01-24T12:31:27Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractA surface plasmon resonance-enhanced total internal reflection ellipsometric (SPRe-TIRE) aptasensor is reported for the determination of the carcinoembryonic antigen (CEA). A gold nanofilm-coated SF10 glass slide was modified with electrochemical diazonium salt reduction and gold nanoparticles (AuNPs) to form a sensor. Next, a specific aptamer for CEA was immobilized on the AuNPs via self-assembly. The platform was characterized by X-ray photoelectron spectroscopy, ellipsometry, and cyclic voltammetry for each step of the preparation of the sensor. CEA aptamers with different affinities were used. SPRe-TIRE employed total internal reflection geometry and AuNPs to enhance plasmon resonance for the sensitive and selective determination of CEA in human serum. The working range of the aptasensor was from 0.01 to 500 ng/mL with an optimum detection limit of 0.1 pg/mL.
dc.description.sponsorshipTUBITAK (Scientific and Technological Research Council of Turkey) [122Z678]
dc.description.sponsorshipThis work was supported by TUBITAK (Scientific and Technological Research Council of Turkey) by project number 122Z678.
dc.identifier.doi10.1080/10739149.2023.2242921
dc.identifier.endpage219
dc.identifier.issn1073-9149
dc.identifier.issn1525-6030
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85166968824
dc.identifier.scopusqualityQ2
dc.identifier.startpage203
dc.identifier.urihttps://doi.org/10.1080/10739149.2023.2242921
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5890
dc.identifier.volume52
dc.identifier.wosWOS:001042461500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofInstrumentation Science & Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectCarcinoembryonic antigen (CEA)
dc.subjectsurface plasmon resonance-enhanced total internal reflection ellipsometry (SPRe-TIRE)
dc.subjectaptasensor
dc.subjectcyclic voltammetry (CV)
dc.titleDetermination of carcinoembryonic antigen (CEA) by surface plasmon resonance-enhanced total internal reflection ellipsometry (SPRe-TIRE)
dc.typeArticle

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