Apoptotic efficiency of capecitabine and 5-fluorouracil on human cancer cells through TRPV1 channels

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dc.contributor.authorÖvey, İshak Suat
dc.contributor.authorGüler, Yılmaz
dc.date.accessioned2021-02-19T21:16:18Z
dc.date.available2021-02-19T21:16:18Z
dc.date.issued2020
dc.departmentALKÜ
dc.description.abstractThe expression of transient receptor potential protein channels increases intensively colon and breast cancer cells. We aimed to reveal the role of 5-fluorouracil (5FU) and capecitabine along with Transient Receptor Potential Vanilloid 1 (TRPV1) channels in breast and colon cancer cells. Breast (MCF-7) and colon (Caco-2) cells were cultured and the study was planned as 7 main groups. Cells in the group were incubated with 5FU and capecitabine for 24 h and then incubated with TRPV1 channel antagonist capsazepine and stimulator capsaicin. The effects of medicines were investigated on molecular pathways of apoptosis. It was concluded that the administration of TRPV1 channel stimulator capsaicin in both cancer cells significantly increased the degree of intracellular Ca2+ levels and apoptosis levels compared to the control group whereas, the use of TRPV1 channel inhibitor capsazepine, significantly decreased the degree of apoptosis levels. The apoptotic effects of 5FU and capecitabine on both colon and breast cancer cells are directly related to TRPV1 channels and TRPV1 channels play an important role in the apoptosis. The apoptotic cell lines activity of capecitabine was higher in breast cancer cells, while that of 5FU was more pronounced in colon cancer cells.
dc.identifier.endpage72en_US
dc.identifier.issn0301-1208
dc.identifier.issn0975-0959
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage64en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12868/369
dc.identifier.volume57en_US
dc.identifier.wosWOS:000527797600008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherNatl Inst Science Communication-Niscair
dc.relation.ispartofIndian Journal of Biochemistry & Biophysics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectApoptosis
dc.subjectBreast and colorectal cancers
dc.subjectCapsaicin
dc.subjectCapsazepine
dc.subjectChemotherapy
dc.subjectOsteosarcoma
dc.titleApoptotic efficiency of capecitabine and 5-fluorouracil on human cancer cells through TRPV1 channels
dc.typeArticle

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