Effects of Epigallocatechin Gallate on the Cytotoxicity of Epirubicin-HCl in Lung Cancer Cells

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dc.contributor.authorErdogan, Ayse
dc.contributor.authorOzkan, Aysun
dc.date.accessioned2026-01-24T12:29:20Z
dc.date.available2026-01-24T12:29:20Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractBackground: Studies have shown that epigallocatechin-3-gallate (EGCG), which is present in green tea at a higher rate than other components, has an additive or synergistic cytotoxic effect when applied with different anticancer drugs and reduces the side effects caused by anticancer drugs. It is known that the order of administration of drugs in combined applications also affects cytotoxicity. In this context, our study determined the most effective application sequence by evaluating the cytotoxic responses of epirubicin-HCl and EGCG according to the different application orders in A-549 cells (NSCLC). Methods: To demonstrate the apoptotic activity, we detected changes in mRNA ratios of Bax, a pro-apoptotic gene, and Bcl-2, an anti-apoptotic gene (Bax/Bcl2), as well as changes in the activity of caspase 3/7 enzyme. To demonstrate the effect of oxidative stress generation, we investigated changes in glutathione peroxidase activity. Results: It was observed that the cell viability of A-549 cells exposed to different concentrations of epirubicin-HCl and EGCG for 48 h decreased depending on the concentration increase. According to the results of cell viability in cells to which epirubicin-HCl (
dc.description.sponsorshipAlanya Alaaddin Keykubat University Scientific Research Projects Unit
dc.description.sponsorshipThe authors wish to thank Alanya Alaaddin Keykubat University Scientific Research Projects Unit for financial support of this work.
dc.identifier.doi10.2174/1570180819999220530153200
dc.identifier.endpage87
dc.identifier.issn1570-1808
dc.identifier.issn1875-628X
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85146504002
dc.identifier.scopusqualityQ3
dc.identifier.startpage77
dc.identifier.urihttps://doi.org/10.2174/1570180819999220530153200
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5289
dc.identifier.volume20
dc.identifier.wosWOS:000936060400008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofLetters in Drug Design & Discovery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectEpirubicin-HCl
dc.subjectcombined therapy
dc.subjectepigallocatechin-3-gallate
dc.subjectapoptotic effect
dc.subjectlung cancer
dc.subjectcytotoxicity
dc.titleEffects of Epigallocatechin Gallate on the Cytotoxicity of Epirubicin-HCl in Lung Cancer Cells
dc.typeArticle

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