Preparation and Characterization of Polyethylene Glycol Functional Hydroxyapatite/Polycaprolactone Electrospun Biomembranes for Bone Tissue Engineering Applications

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dc.authorid0000-0003-2053-2197
dc.authorid0000-0003-2810-8294
dc.authorid0000-0001-9855-7437
dc.contributor.authorYavuz, Emre
dc.contributor.authorErdem, Ramazan
dc.contributor.authorKucuksayan, Ertan
dc.contributor.authorAkarsu, Esin
dc.contributor.authorAkarsu, Murat
dc.date.accessioned2026-01-24T12:31:01Z
dc.date.available2026-01-24T12:31:01Z
dc.date.issued2021
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractSurfaces of previously synthesized Hydroxyapatite particles (HAP) have been modified with polyethylene glycol functional silane (PEG-400Si). For the surface modification of HAP, firstly, synthesis of PEG-400Si was performed by urethane reaction of hydroxyl and isocyanate groups. Then, HAP was synthesized by sol-gel method. Afterwards, surface modification of HAP was realized with PEG-400Si. SEM, TEM, XRD and FTIR analyses were utilized to characterize the morphology and structural properties of the synthesized and modified particles. Results revealed that the surface of HAP was modified successfully and the crystal structure of HAP was not changed after modification. Electrospinning process was conducted to obtain unmodified and modified HAP incorporated nanofibrous biomembranes and the characteristics and biological performances of these membranes have been compared to each other. SEM analysis presented that defect-free and round shape nanofibers obtained and the fiber diameter ranged from 230 +/- 114 nm to 760 +/- 291 nm. In vitro biological evaluations revealed that all electrospun nanofibrous biomembranes were nontoxic and the one with PCL/PEG-400Si-HAP exhibited greatest cellular protein expression approximately 1.5 times higher than the PCL biomembrane for 24 h, 48 h and 72 h.
dc.description.sponsorshipAkdeniz University [FBG-2019-5005]
dc.description.sponsorshipAuthors would like to thank to Prof. Dr. Erturul Arpac and his Sol-Gel research group at the Chemistry Department of Akdeniz University for their great support during the experimental stage of this study. This project was funded by Akdeniz University with the project code: FBG-2019-5005.
dc.identifier.doi10.1007/s12221-021-0560-6
dc.identifier.endpage1284
dc.identifier.issn1229-9197
dc.identifier.issn1875-0052
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85103351198
dc.identifier.scopusqualityQ2
dc.identifier.startpage1274
dc.identifier.urihttps://doi.org/10.1007/s12221-021-0560-6
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5594
dc.identifier.volume22
dc.identifier.wosWOS:000633327500027
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherKorean Fiber Soc
dc.relation.ispartofFibers and Polymers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectHydroxyapatite
dc.subjectSurface modification
dc.subjectElectrospinning
dc.subjectSol-gel
dc.subjectBiomembrane
dc.titlePreparation and Characterization of Polyethylene Glycol Functional Hydroxyapatite/Polycaprolactone Electrospun Biomembranes for Bone Tissue Engineering Applications
dc.typeArticle

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