Evaluation of the effect of a natural monoterpenic phenol on the cytotoxicity of carfilzomib

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dc.contributor.authorErdogan, Ayse
dc.date.accessioned2026-01-24T12:00:53Z
dc.date.available2026-01-24T12:00:53Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractAim: The aim of this study was to reveal whether carfilzomib, proteasome inhibitor, and carvacrol, a natural monoterpenic phenol, causes cytotoxic and apoptotic effects and oxidative stress on A-549 cells. Materials and Methods: Lactate dehydrogenase (LDH) activity test was used. Changes in caspase 3 and glutathione peroxidase enzyme activities in cells were determined. Results: It was determined that carfilzomib alone and together with carvacrol caused a raise in the activities of lactate dehydrogenase (LDH), glutathione peroxidase and apoptotic enzyme, caspase-3 activity, compared to the control. Conclusion: Our study showing that carfilzomib alone and together with carvacrol gave different responses may be guiding in determining new strategies to be applied in lung cancer treatment.
dc.identifier.doi10.30569/adiyamansaglik.1522904
dc.identifier.endpage199
dc.identifier.issn2458-9179
dc.identifier.issue3
dc.identifier.startpage189
dc.identifier.trdizinid1294599
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1294599
dc.identifier.urihttps://doi.org/10.30569/adiyamansaglik.1522904
dc.identifier.urihttps://hdl.handle.net/20.500.12868/3797
dc.identifier.volume10
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofAdıyaman Üniversitesi Sağlık Bilimleri Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR-Dizin_20260121
dc.subjectLung cancer
dc.subjectCarfilzomib
dc.subjectCarvacrol
dc.subjectApoptotic effect
dc.titleEvaluation of the effect of a natural monoterpenic phenol on the cytotoxicity of carfilzomib
dc.typeArticle

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