Evaluation of the effect of a natural monoterpenic phenol on the cytotoxicity of carfilzomib
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Tarih
2024
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: The aim of this study was to reveal whether carfilzomib, proteasome inhibitor, and carvacrol, a natural monoterpenic phenol, causes cytotoxic and apoptotic effects and oxidative stress on A-549 cells. Materials and Methods: Lactate dehydrogenase (LDH) activity test was used. Changes in caspase 3 and glutathione peroxidase enzyme activities in cells were determined. Results: It was determined that carfilzomib alone and together with carvacrol caused a raise in the activities of lactate dehydrogenase (LDH), glutathione peroxidase and apoptotic enzyme, caspase-3 activity, compared to the control. Conclusion: Our study showing that carfilzomib alone and together with carvacrol gave different responses may be guiding in determining new strategies to be applied in lung cancer treatment.
Açıklama
Anahtar Kelimeler
Lung cancer, Carfilzomib, Carvacrol, Apoptotic effect
Kaynak
Adıyaman Üniversitesi Sağlık Bilimleri Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
10
Sayı
3
