SARS-CoV-2 Mutations and their Viral Variants

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dc.contributor.authorCoşar, Begüm
dc.contributor.authorKaragülleoğlu, Zeynep Yağmur
dc.contributor.authorÜnal, Sinan
dc.contributor.authorİnce, Ahmet Turan
dc.contributor.authorUncuoğlu, Dilruba Beyza
dc.contributor.authorTuncer, Gizem
dc.contributor.authorKılınç, Buğrahan Regaip
dc.contributor.authorÖzkan, Yunus Emre
dc.contributor.authorÖzkoç, Hikmet Ceyda
dc.contributor.authorDemir, İbrahim Naki
dc.contributor.authorEker, Ali
dc.contributor.authorKaragöz, Feyzanur
dc.contributor.authorŞimşek, Said Yasin
dc.contributor.authorYaşar, Bünyamin
dc.contributor.authorPala, Mehmetcan
dc.contributor.authorDemir, Ayşegül
dc.contributor.authorAtak, İrem Naz
dc.contributor.authorMendi, Ayşegül Hanife
dc.contributor.authorBengi, Vahdi Umut
dc.contributor.authorCengiz Seval, Güldane
dc.contributor.authorGüneş Altuntaş, Evrim
dc.contributor.authorKılıç, Pelin
dc.contributor.authorDemir-Dora, Devrim
dc.date.accessioned2023-10-09T06:56:49Z
dc.date.available2023-10-09T06:56:49Z
dc.date.issued2022
dc.departmentALKÜ
dc.description.abstractMutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occur spontaneously during replication. Thousands of mutations have accumulated and continue to since the emergence of the virus. As novel mutations continue appearing at the scene, naturally, new variants are increasingly observed. Since the first occurrence of the SARS-CoV-2 infection, a wide variety of drug compounds affecting the binding sites of the virus have begun to be studied. As the drug and vaccine trials are continuing, it is of utmost importance to take into consideration the SARS-CoV-2 mutations and their respective frequencies since these data could lead the way to multi-drug combinations. The lack of effective therapeutic and preventive strategies against human coronaviruses (hCoVs) necessitates research that is of interest to the clinical applications. The reason why the mutations in glycoprotein S lead to vaccine escape is related to the location of the mutation and the affinity of the protein. At the same time, it can be said that variations should occur in areas such as the receptor-binding domain (RBD), and vaccines and antiviral drugs should be formulated by targeting more than one viral protein. In this review, a literature survey in the scope of the increasing SARS-CoV-2 mutations and the viral variations is conducted. In the light of current knowledge, the various disguises of the mutant SARS-CoV-2 forms and their apparent differences from the original strain are examined as they could possibly aid in finding the most appropriate therapeutic approaches.
dc.identifier.doi10.1016/j.cytogfr.2021.06.001
dc.identifier.endpage22en_US
dc.identifier.issue63en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage10en_US
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85115962112&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=20c4fe371b9b908d4f7e419f791331ff&sot=aff&sdt=cl&cluster=scofreetoread%2c%22all%22%2ct&sl=72&s=AF-ID%28%22Alanya+Alaaddin+Keykubat+University%22+60198720%29+AND+SUBJAREA%28MEDI%29&relpos=64&citeCnt=72&searchTerm=
dc.identifier.urihttps://hdl.handle.net/20.500.12868/2389
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1359610121000538?pes=vor&utm_source=scopus&getft_integrator=scopus
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofCytokine and Growth Factor Reviews
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCOVID-19
dc.subjectMutation
dc.subjectReceptor-binding domain
dc.subjectSARS-CoV-2
dc.subjectSpike protein
dc.subjectViral variants
dc.titleSARS-CoV-2 Mutations and their Viral Variants
dc.typeArticle

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