Investigation the Effect of Human Recombinant Epidermal Growth Factor on Rotator Cuff Healing: An Experimental Model

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dc.authorid0000-0001-5797-1287
dc.authorid0000-0003-3587-2725
dc.authorid0000-0002-9012-8053
dc.contributor.authorGulcu, Anil
dc.contributor.authorTurhan, Egemen
dc.contributor.authorAslan, Ahmet
dc.contributor.authorCayli, Sevil
dc.contributor.authorAlimogullari, Ebru
dc.contributor.authorAkcan, Gulben
dc.date.accessioned2026-01-24T12:31:24Z
dc.date.available2026-01-24T12:31:24Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObjective To investigate the effectiveness of human recombinant epidermal growth factor in the healing of rotator cuff tear in the rabbit shoulder. Methods Rotator cuff tears (RCTs) were experimentally created on both shoulders of 20 New Zealand rabbits. The rabbits were divided into the following groups: RCT (sham group; n = 5), RCT + EGF (EGF group; n = 5), RCT + transosseous repair (repair group; n = 5), and RCT + EGF + transosseous repair (combined repair + EGF group; n = 5). All rabbits were then observed for 3 weeks, and biopsies were taken from the right shoulders in the third week. After three more weeks of observation, all rabbits were sacrificed, and a biopsy removed from their left shoulders. All biopsy material was stained with haematoxylin & eosin (H&E) and vascularity, cellularity, the proportion of fibers and the number of fibrocartilage cells were evaluated under light microscope. Results The highest collagen amount and the most regular collagen sequence was detected in the combined repair + EGF group. The repair group and the EGF group showed higher fibroblastic activity and capillary formation when compared with the sham group, but the highest fibroblastic activity and capillary formation with highest vascularity was detected in the combined repair + EGF group ( p < 0.001). EGF seems to improve wound healing in the repair of RCT. The EGF application alone, even without repair surgery, seems to be beneficial to RCT healing. Conclusion In addition to rotator cuff tear repair, application of human recombinant epidermal growth factor has an effect on rotator cuff healing in rabbit shoulders.
dc.description.sponsorshipNo Statement Availabler No Statement Availabler No Statement Available
dc.identifier.doi10.1055/s-0042-1750832
dc.identifier.endpage278
dc.identifier.issn0102-3616
dc.identifier.issn1982-4378
dc.identifier.issue2
dc.identifier.pmid37252305
dc.identifier.startpage271
dc.identifier.urihttps://doi.org/10.1055/s-0042-1750832
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5837
dc.identifier.volume58
dc.identifier.wosWOS:001489070000005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGeorg Thieme Verlag Kg
dc.relation.ispartofRevista Brasileira De Ortopedia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectcicatriza & ccedil;& atilde;o
dc.subjectfator de crescimento epid & eacute;rmico
dc.subjectles & otilde;es do manguito rotador
dc.subjectrotator cuff injuries
dc.subjectwound healing
dc.subjectepidermal growth factor
dc.titleInvestigation the Effect of Human Recombinant Epidermal Growth Factor on Rotator Cuff Healing: An Experimental Model
dc.typeArticle

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