Development of PLA-Based Composite Nanofibers Incorporating Tricalcium Phosphate and Graphene Oxide for Bone Tissue Engineering

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dc.authorid0000-0001-7253-8270
dc.authorid0000-0001-5594-1551
dc.contributor.authorAyhan, Selin Sude
dc.contributor.authorAkdag, Atakan
dc.contributor.authorTopcu, Beyza
dc.contributor.authorIlhan, Elif
dc.contributor.authorBedir, Tuba
dc.contributor.authorSahin, Ali
dc.contributor.authorYuka, Selcen Ari
dc.date.accessioned2026-01-24T12:30:51Z
dc.date.available2026-01-24T12:30:51Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractBone tissue engineering has emerged as a promising approach for aiming to repair the damaged tissue using biomaterials. In this study, composite polylactic acid (PLA) matrices were produced via electrospinning incorporating 2 wt% tricalcium phosphate (TCP) and varying concentrations of graphene oxide (GO) (0.4, 0.8, and 1.2 wt%). The morphological properties and chemical compositions were analyzed using scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR), respectively. Differential scanning calorimetry (DSC) was employed to study the thermal properties of the nanofibers. Swelling and degradation behaviors were assessed, along with GO release kinetics. Overall, the novelty of this work lies in the optimized integration of GO, particularly at 0.4 wt%, which provides enhanced mechanical properties and superior biocompatibility. This composition exhibited enhanced swelling capacity and the lowest degradation rate over 30 days, supporting structural integrity and scaffold stability. GO release from the nanofibers followed a sustained and controlled profile, minimizing initial burst effects. Notably, PLA/TCP/0.4 GO achieved the highest hFOB cell viability on days 3 and 7. Collectively, these results identify 0.4 wt% GO as the optimal concentration, offering a well-balanced combination of mechanical robustness, degradation resistance, and biological performance for bone tissue engineering applications.
dc.identifier.doi10.1002/slct.202502405
dc.identifier.issn2365-6549
dc.identifier.issue33
dc.identifier.scopus2-s2.0-105014524550
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1002/slct.202502405
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5486
dc.identifier.volume10
dc.identifier.wosWOS:001556720600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistryselect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectbeta-Tricalcium phosphate (TCP)
dc.subjectBone tissue engineering
dc.subjectElectrospinning
dc.subjectGraphene oxide (GO)
dc.subjectPolylactic acid (PLA)
dc.titleDevelopment of PLA-Based Composite Nanofibers Incorporating Tricalcium Phosphate and Graphene Oxide for Bone Tissue Engineering
dc.typeArticle

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