The effect of exercise intensity on ischemia/reperfusion injury and myokine profile in diabetic cardiomyopathy

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dc.authorid0000-0002-8008-6515
dc.authorid0000-0002-3394-2438
dc.authorid0000-0001-9056-0025
dc.authorid0000-0003-1609-6847
dc.contributor.authorAkat, F.
dc.contributor.authorTatar, Y.
dc.contributor.authorCelik, H.
dc.contributor.authorFicicilar, H.
dc.contributor.authorDursun, A. D.
dc.contributor.authorBastug, M.
dc.date.accessioned2026-01-24T12:29:04Z
dc.date.available2026-01-24T12:29:04Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractDiabetes is a metabolic disorder characterised by hyperglycaemia. The diabetic heart becomes more susceptible to ischemic injury. Although exercise induces a cardioprotective phenotype, the determination of accurate protocol is crucial. We compared two different exercise intensities in the diabetes model and evaluated the role of myokines in exercise-induced cardioprotection. Male, adult, Wistar albino rats were used (n = 20 each). First, animals were divided into two groups: Non-Diabetic (ND), Diabetic (DM); then groups were further divided into subgroups: Sedentary (S), Training-1 (T1 =10 m/min, 00 inclination), and Training-2 (T2 = 20 m/min, 100 inclination). Diabetes was induced by streptozotocin (60 mg/kg; i.p.). Animals exercised on a treadmill 5 days/a week for 6 weeks. Then, hearts were attached to the Langendorff apparatus and baseline functional parameters were measured. After 30'/120'I/R protocol, infarct size was evaluated with tetrazolium chloride staining. Interleukin-6, FNDC5, and myonectin levels were measured both in the soleus and the left ventricle. We observed cardiac hypertrophy and impaired baseline LV function in diabetes. Infarct size was significantly larger in diabetics and only T1 decreased the infarct size whereas T2 further aggravated it. Moreover, post-ischemic recovery was worst in diabetic-T2 group. Irisin and myonectin levels were decreased in the soleus muscle of diabetic animals. T1 increased the myonectin levels in the left ventricle of non-diabetics, and this effect was blunted in diabetic-T1 animals. As a conclusion, light-intensity exercise is a better approach to prevent ischemic damage in diabetes besides moderate intensity may be hazardous in diabetic population.
dc.description.sponsorshipAnkara University Sci-entific Research Projects (AU BAP) [15A023006, 21H0230004]
dc.description.sponsorshipThis study was supported by Ankara University Sci-entific Research Projects (AU BAP) (Project Number: 15A023006 and 21H0230004) . We want to express our gratitude to Prof. Frantisek Kolar for his valuable intel-lectual contributions after reviewing the initial version of the manuscript.
dc.identifier.doi10.1163/17552559-00001060
dc.identifier.endpage339
dc.identifier.issn1755-2540
dc.identifier.issn1755-2559
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85204068630
dc.identifier.scopusqualityQ3
dc.identifier.startpage327
dc.identifier.urihttps://doi.org/10.1163/17552559-00001060
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5117
dc.identifier.volume20
dc.identifier.wosWOS:001350542100002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherBrill
dc.relation.ispartofComparative Exercise Physiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectexercise
dc.subjectdiabetes
dc.subjectischemia/reperfusion
dc.subjectmyokine
dc.titleThe effect of exercise intensity on ischemia/reperfusion injury and myokine profile in diabetic cardiomyopathy
dc.typeArticle

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