Noninvasive assessment of oral lesions using elastic light single-scattering spectroscopy: a pilot study

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dc.contributor.authorSırcan Küçüksayan, Aslınur
dc.contributor.authorYaprak, Neslihan
dc.contributor.authorDerin, Alper Tunga
dc.contributor.authorÖzbudak, İrem Hicran
dc.contributor.authorTurhan, Murat
dc.contributor.authorCanpolat, Murat
dc.date.accessioned2021-02-19T21:20:50Z
dc.date.available2021-02-19T21:20:50Z
dc.date.issued2020
dc.departmentALKÜ
dc.description.abstractPurpose: In the present study, we investigated the potential application of elastic light single-scattering spectroscopy (ELSSS) as a noninvasive, adjunctive tool to differentiate between malignant and benign oral lesions in vivo. Methods: ELSSS spectra were acquired from 52 oral lesions of 47 patients prior to surgicalbiopsy using a single optical fiber probe. The sign of the spectral slope was used as a diagnostic parameter and was compared to the histopathology findings to obtain sensitivity and specificity of the ELSSS system in differentiating between benign and malignant tissues. Results: The sign of the spectral slope was positive for the benign tissues and negative for the malignant tissues. Nine malignant lesions and one high-grade dysplasia were correctly classified as cancerous. Six out of the ten low-grade dysplasia were correctly classified as cancerous, and four of them were misclassified as benign. Thirty benign lesions were correctly classified as benign, and two were misclassified as malignant. Our results indicate that the sign of the spectral slope enables the differentiation between malignant and benign oral lesions with a sensitivity of 80% and specificity of 94%. Conclusions: ELSSS has the potential to be developed as an adjunctive screening tool in the noninvasive evaluation of oral lesions in vivo. This new diagnostic system may reduce the number of unnecessary biopsies. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
dc.identifier.doi10.1007/s00405-020-05824-z
dc.identifier.endpage1472en_US
dc.identifier.issn0937-4477
dc.identifier.issue5en_US
dc.identifier.pmid32016524
dc.identifier.scopusqualityQ1
dc.identifier.startpage1467en_US
dc.identifier.urihttps://doi.org/10.1007/s00405-020-05824-z
dc.identifier.urihttps://hdl.handle.net/20.500.12868/717
dc.identifier.volume277en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofEuropean Archives of Oto-Rhino-Laryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectElastic light single-scattering spectroscopy
dc.subjectOral cancer
dc.subjectOral lesions
dc.subjectReal-time diagnosis
dc.titleNoninvasive assessment of oral lesions using elastic light single-scattering spectroscopy: a pilot study
dc.typeArticle

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