Evaluation of the Presence and Importance of PD-L1 Expression in Head-neck Squamosus Cell Carcinomas and Premalign Lesions

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dc.contributor.authorGunizi, Ozlem Ceren
dc.contributor.authorGunizi, Huseyin
dc.date.accessioned2026-01-24T12:29:26Z
dc.date.available2026-01-24T12:29:26Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractBackground: Programmed Death-Ligand 1 (PD-L1) is a cell membrane protein found on the surface of cancer cells, immune system cells in the tumor microenvironment, and various healthy tissues. Moreover, it plays a key role in suppressing the immune system. Objectives: We aim to explain the presence of PD-L1 in Head-Neck Squamosus Cell Carcinomas (HNSCC) and premalign lesions by immunohistochemical method. Methods: Our retrospective study included 22 patients with HNSCC (15(68.1%) Oral cavity and 7(31.9%) Oropharynx), 20 patients with oral lichen planus, and 14 patients with normal oral cavity mucosa. In the evaluation of PD-L1 antibodies applied immunohistochemically in patients with HNSCC, the percentage of tumor cells showing membranous staining with PD-L1 antibodies was calculated. Results: The mean age of HNSCC patients participating in the study was 52.24 +/- 11.7 years, the mean age of oral lichen planus patients was 34.10 +/- 9.8 years, and the control patients' mean age was 31.42 +/- 10.6 years. The rate of PD-L1 staining of tumor cells of HNSCC patients was significantly higher than the control group (P=0.001). Conclusion: The importance of PD-L1 expression in HNSCC and precancerous lesions of the oral cavity is remarkable, and the values may be related to the pathophysiology of these diseases.
dc.identifier.doi10.32592/ircmj.2023.25.6.2567
dc.identifier.issn2074-1804
dc.identifier.issn2074-1812
dc.identifier.issue6
dc.identifier.urihttps://doi.org/10.32592/ircmj.2023.25.6.2567
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5363
dc.identifier.volume25
dc.identifier.wosWOS:001055472400007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherDubai Iranian Hosp
dc.relation.ispartofIranian Red Crescent Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectCarcinoma
dc.subjectHead and neck cancer
dc.subjectOral lichen planus
dc.subjectPD-L1
dc.subjectPrecancerous lesions
dc.titleEvaluation of the Presence and Importance of PD-L1 Expression in Head-neck Squamosus Cell Carcinomas and Premalign Lesions
dc.typeArticle

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