Evaluation of the Presence and Importance of PD-L1 Expression in Head-neck Squamosus Cell Carcinomas and Premalign Lesions
[ X ]
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Dubai Iranian Hosp
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Programmed Death-Ligand 1 (PD-L1) is a cell membrane protein found on the surface of cancer cells, immune system cells in the tumor microenvironment, and various healthy tissues. Moreover, it plays a key role in suppressing the immune system. Objectives: We aim to explain the presence of PD-L1 in Head-Neck Squamosus Cell Carcinomas (HNSCC) and premalign lesions by immunohistochemical method. Methods: Our retrospective study included 22 patients with HNSCC (15(68.1%) Oral cavity and 7(31.9%) Oropharynx), 20 patients with oral lichen planus, and 14 patients with normal oral cavity mucosa. In the evaluation of PD-L1 antibodies applied immunohistochemically in patients with HNSCC, the percentage of tumor cells showing membranous staining with PD-L1 antibodies was calculated. Results: The mean age of HNSCC patients participating in the study was 52.24 +/- 11.7 years, the mean age of oral lichen planus patients was 34.10 +/- 9.8 years, and the control patients' mean age was 31.42 +/- 10.6 years. The rate of PD-L1 staining of tumor cells of HNSCC patients was significantly higher than the control group (P=0.001). Conclusion: The importance of PD-L1 expression in HNSCC and precancerous lesions of the oral cavity is remarkable, and the values may be related to the pathophysiology of these diseases.
Açıklama
Anahtar Kelimeler
Carcinoma, Head and neck cancer, Oral lichen planus, PD-L1, Precancerous lesions
Kaynak
Iranian Red Crescent Medical Journal
WoS Q Değeri
Q3
Scopus Q Değeri
Cilt
25
Sayı
6
