The effects of zoledronic acid treatment on fracture healing, morbidity and mortality in elderly patients with osteoporotic hip fractures

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dc.contributor.authorSargın, Serdar
dc.contributor.authorKonya, Mehmet Nuri
dc.contributor.authorGülcü, Anıl
dc.contributor.authorAslan, Ahmet
dc.date.accessioned2021-02-19T21:20:46Z
dc.date.available2021-02-19T21:20:46Z
dc.date.issued2019
dc.departmentALKÜ
dc.description.abstractBackground: In this study, the effects of zoledronic acid (ZolA) administered at different times to patients undergoing surgical treatment for hip fracture were investigated. Materials and methods: Ninety patients who underwent surgical treatment for osteoporotic (OP) hip fractures between February 2013 and September 2016 in our hospital were included in the study. After surgical treatment, patients were allocated into three groups: group I—patients who had osteosynthesis using proximal femoral nail (PFN) for an intertrochanteric fracture of the femur were given ZolA within 1 week after fracture and before discharge; group II—patients who had osteosynthesis using the PFN for an intertrochanteric fracture of the femur were given ZolA within 1 month after fracture post discharge; group III—patients in the same age group who had a hemiarthroplasty (HA) for an intertrochanteric fracture of the femur were administered ZolA before discharge. In addition, all patients were given daily oral calcium and vitamin D3. The Radiographic Union Score for Hip (RUSH), Harris Hip Score (HHS), and bone mineral density (BMD) were used at the follow-up as evaluation criteria, and complications were noted. Results: There were no significant differences between groups in terms of demographic data and laboratory outcomes (p > 0.05). Radiographic Union Score for Hip scores were similar between groups I and II (p > 0.05). Fracture union occurred by the sixth month in all patients whose results were evaluated. No statistically significant difference was found between three groups (p > 0.05). There was no difference between the three groups in the hip and vertebrae BMD and t scores (p > 0.05). When t and BMD scores before treatment were compared with those at 1 year after treatment, a benefit from ZolA treatment was observed in all three groups (p < 0.05). Conclusion: This study shows that the timing of ZolA administration has no effect on fracture healing and complication incidence in elderly patients with hip fractures. In addition, ZolA was found to be beneficial in increasing BMD of both femur and vertebra in all groups, but there was no significant difference between the groups. Clinical significance: The study demonstrated that ZolA may be used early in the treatment of osteoporotic hip fractures with PFN. © The Author(s). 2019.
dc.identifier.doi10.5005/jp-journals-10080-1439
dc.identifier.endpage131en_US
dc.identifier.issn1828-8936
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage126en_US
dc.identifier.urihttps://doi.org/10.5005/jp-journals-10080-1439
dc.identifier.urihttps://hdl.handle.net/20.500.12868/675
dc.identifier.volume14en_US
dc.indekslendigikaynakScopus
dc.institutionauthor0-belirlenecek
dc.language.isoen
dc.publisherJaypee Brothers Medical Publishers (P) Ltd
dc.relation.ispartofStrategies in Trauma and Limb Reconstruction
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFracture healing
dc.subjectHarris Hip Score
dc.subjectOsteoporotic hip fracture
dc.subjectRUSH score
dc.subjectZoledronic acid
dc.titleThe effects of zoledronic acid treatment on fracture healing, morbidity and mortality in elderly patients with osteoporotic hip fractures
dc.typeArticle

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