Elevated Blood Levels of VEGF Exhibiting Positive Correlation with HIF-1? in Obesity: A Single Center Study

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dc.contributor.authorUluergüven, Nazmiye
dc.contributor.authorEksi, Durkadin Demir
dc.contributor.authorMaytalman, Erkan
dc.contributor.authorGunesacar, Ramazan
dc.date.accessioned2026-01-24T12:01:34Z
dc.date.available2026-01-24T12:01:34Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractAim: The objective of this study was to investigate the relevance of plasma hypoxia-inducible factor-1 alpha (HIF-1?) and vascular endothelial growth factor (VEGF) levels in obesity and their associations with body mass index (BMI), body fat percentage, and waist to-hip ratio. Material and Methods: The study included 45 obese subjects and 28 healthy controls recruited from a private clinic in Manavgat, Antalya. The measurement of BMI, percentage of body fat, and waist-to-hip ratio was conducted in all subjects using a bioelectrical impedance analysis device. The plasma levels of HIF-1? and VEGF were measured using the micro-ELISA method. Results: In the Mann-Whitney U test, HIF-1? levels were similar in obese subjects (median=1.439 ng/L [Interquartile range (IQR)=11.62, min-max=0.904-12.53] and control group (median=1.377 ng/L [1.323, 0.852-2.175], p=0.0821). VEGF levels were found to be significantly higher in obese subjects compared to the controls (medians; 729.8 ng/L [5515, 485.3-6000] vs. 589.5 ng/L, [416.8, 396.4-813.2], respectively, p
dc.identifier.doi10.25048/tudod.1551609
dc.identifier.endpage8
dc.identifier.issn2587-0335
dc.identifier.issn2587-0572
dc.identifier.issue1
dc.identifier.startpage1
dc.identifier.trdizinid1329866
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1329866
dc.identifier.urihttps://doi.org/10.25048/tudod.1551609
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4421
dc.identifier.volume9
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTürkiye Diyabet ve Obezite Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TR-Dizin_20260121
dc.subjectObesity
dc.subjectBody mass index
dc.subjectVascular endothelial growth factor
dc.subjectHypoxia-inducible factor 1 alpha
dc.titleElevated Blood Levels of VEGF Exhibiting Positive Correlation with HIF-1? in Obesity: A Single Center Study
dc.typeArticle

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