Elevated Blood Levels of VEGF Exhibiting Positive Correlation with HIF-1? in Obesity: A Single Center Study
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Tarih
2025
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: The objective of this study was to investigate the relevance of plasma hypoxia-inducible factor-1 alpha (HIF-1?) and vascular endothelial growth factor (VEGF) levels in obesity and their associations with body mass index (BMI), body fat percentage, and waist to-hip ratio. Material and Methods: The study included 45 obese subjects and 28 healthy controls recruited from a private clinic in Manavgat, Antalya. The measurement of BMI, percentage of body fat, and waist-to-hip ratio was conducted in all subjects using a bioelectrical impedance analysis device. The plasma levels of HIF-1? and VEGF were measured using the micro-ELISA method. Results: In the Mann-Whitney U test, HIF-1? levels were similar in obese subjects (median=1.439 ng/L [Interquartile range (IQR)=11.62, min-max=0.904-12.53] and control group (median=1.377 ng/L [1.323, 0.852-2.175], p=0.0821). VEGF levels were found to be significantly higher in obese subjects compared to the controls (medians; 729.8 ng/L [5515, 485.3-6000] vs. 589.5 ng/L, [416.8, 396.4-813.2], respectively, p
Açıklama
Anahtar Kelimeler
Obesity, Body mass index, Vascular endothelial growth factor, Hypoxia-inducible factor 1 alpha
Kaynak
Türkiye Diyabet ve Obezite Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
9
Sayı
1
