The Protective Effects of Geraniol Against Damage of Short Term Renal Ischemia-Reperfusion in Rats

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dc.authorid0000-0001-5562-5938
dc.authorid0000-0003-1095-2382
dc.contributor.authorDanis, Seren
dc.contributor.authorCan, Senanur
dc.contributor.authorYildiz, Fatma
dc.contributor.authorYilmaz, Isil Tan
dc.contributor.authorCanbek, Mediha
dc.contributor.authorYaylaci, Ayse Ozmen
dc.date.accessioned2026-01-24T12:29:18Z
dc.date.available2026-01-24T12:29:18Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractIschemia/reperfusion (I/R) injury is one of the main causes of acute kidney injury. The pathological mechanisms underlying renal I/R injury are complex and remain uncertain. The protective effects of antioxidant properties of geraniol against renal ischemia reperfusion (I/R) damage were investigated in our study. 28 Wistar albino male rats were randomly selected and 4 groups of n = 7 were created. A right kidney nephrectomy surgery was conducted to all groups under anesthesia. 2 ml SF was given to Groups I and II, 50 mg/kg and 100 mg/ kg geraniol were administered intraperitoneally an hour before ischemia to Groups III and IV, respectively. Except for Group I, 45 minutes of ischemia and 4 hours of reperfusion were applied to the groups. At the end of the experiment, parameters related to oxidative stress and inflammation were determined by comparing kidney function, antioxidant enzyme activities and histological changes. Following comparison of BUN and CRE values with CAT and SOD values in tissue samples of Group I and Group II, an increase in Group II was observed and as a result I/R damage formation occurred. Values of geraniol-treated Group III and Group IV approximated to that of Group I, and that the 50 mg/kg geraniol dose proved more effective than 100 mg/kg geraniol.
dc.identifier.doi10.1590/s2175-97902023e21248
dc.identifier.issn1984-8250
dc.identifier.issn2175-9790
dc.identifier.scopus2-s2.0-85158154454
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1590/s2175-97902023e21248
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5244
dc.identifier.volume59
dc.identifier.wosWOS:000975235800001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniv Sao Paulo, Conjunto Quimicas
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.subjectFree Radical
dc.subjectAntioxidant
dc.subjectGeraniol
dc.subjectIschemia Reperfusion
dc.subjectKidney
dc.titleThe Protective Effects of Geraniol Against Damage of Short Term Renal Ischemia-Reperfusion in Rats
dc.typeArticle

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