In Vitro Anti-Aging Activitiy of Arum Dioscoridis with In Silico Prediction of Its Active Compounds

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dc.contributor.authorUckaya, Fatih
dc.date.accessioned2026-01-24T12:26:53Z
dc.date.available2026-01-24T12:26:53Z
dc.date.issued2024
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractArum dioscoridis is a plant that has been used by people for centuries for shortness of breath, asthma, bronchitis, expectorant, intestinal laziness, digestive system, malaria and especially hemorrhoid diseases. The aims of the study are to determine the efficient extraction method by extracting the plant with different methods, to investigate the antioxidant and anti-aging effects of the extracts, and to perform in silico prediction analyzes of the active molecules of the plant. The plant was extracted using ethanol by maceration, ultrasonic wave extraction, and soxhlet extraction. The antioxidant and anti-aging potential of the obtained extracts were investigated. To determine antioxidant activity, DPPH free radical scavenging, cupric ion reduction and iron ion reduction methods were applied. Anti-aging activity was determined by inhibiting the enzyme elastase. Additionally, the active components of the ethanol extract of the plant were determined using PASSonline, LAZAR, ADMETlab 2.0 and CLC-pred online prediction programs. The yields obtained from the maceration, ultrasonic wave extraction and soxhlet extraction methods are 8.99 g/100g, 19.94 g/100g and 13.2 g/100g, respectively. The IC50 values from the DPPH method obtained from the maceration ethanol extract, ultrasonic wave ethanol extract, and soxhlet ethanol extract were 3.943 mu g/mL, 2.797 mu g/mL, and 2.273 mu g/mL, respectively. The IC50 values of the extracts obtained from the elastase inhibition method were 3.112 mu g/mL, 3.357 mu g/mL and 2.964 mu g/mL, in the same order. Additionally, the extracts showed inhibition of cupric ions at 1.8 nm, 0.81 nm and 1.79 nm, in the same order. In silico biological activity was determined with the PASSonline program, toxicity with LAZAR and ADMETlab programs, and the effects of active molecules against some cell lines were determined with the CLC-Pred program. As a result, it was determined that the plant has biological activities to protect the skin against aging in silico and in vitro.
dc.description.sponsorshipScientific Research Unit of Bezmialem Vakif University [1.2017/32]; Bezmialem Vakif University
dc.description.sponsorshipThe study was carried out with the project number 1.2017/32 supported by the Scientific Research Unit of Bezmialem Vakif University. The author extends his sincere thanks to Bezmialem Vakif University for financial support.
dc.identifier.endpage399
dc.identifier.issn0253-5106
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85203351841
dc.identifier.scopusqualityQ4
dc.identifier.startpage386
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5007
dc.identifier.volume46
dc.identifier.wosWOS:001301081500007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherChem Soc Pakistan
dc.relation.ispartofJournal of The Chemical Society of Pakistan
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectArum dioscoridis
dc.subjectAnti-aging
dc.subjectAntioxidant
dc.subjectPASSonline
dc.subjectLAZAR
dc.subjectADMETlab.
dc.titleIn Vitro Anti-Aging Activitiy of Arum Dioscoridis with In Silico Prediction of Its Active Compounds
dc.typeArticle

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