The effects of tacrolimus and mycophenolate mofetil on regression of encapsulating peritoneal sclerosis in a rat model

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dc.authorid0000-0002-2893-4484
dc.authorid0000-0002-2864-361X
dc.contributor.authorHuddam, Bulent
dc.contributor.authorSasmaz, Simge
dc.contributor.authorHaberal, Nihan
dc.contributor.authorAzak, Alper
dc.contributor.authorGenek, Dilek Gibyeli
dc.contributor.authorKocak, Gulay
dc.contributor.authorKarakus, Volkan
dc.date.accessioned2026-01-24T12:26:55Z
dc.date.available2026-01-24T12:26:55Z
dc.date.issued2021
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObjective: Encapsulating peritoneal sclerosis (EPS) is a rare, but potentially fatal complication of peritoneal dialysis. Currently, treatment of peritoneal fibrosis is not fully possible yet. In this study, we aimed to demonstrate the effects of tacrolimus therapy on peritoneal fibrosis and inflammation when administered alone or with mycophenolate mofetil (MMF) in the EPS model induced in rats. Methods: Thirty six Wistar albino rats were separated into six equal groups. Group I was the control group. Group II-VI were administered intraperitoneal chlorhexidine (CH) for induced EPS model in rats. Group II, IV, V, VI were administered isotonic liquid, tacrolimus, tacrolimus and concurrently with CH, tacrolimus and MMF together, respectively. Group III was not administered any drug. All peritoneal samples were stained immunohistochemically with matrix metalloproteinase-2 (MMP-2) antibody. Thickness of peritoneal fibrosis, subserosal large collagen fibers, subserosal fibroblast proliferation and subserosal fibrotic matrix deposition were evaluated. Results: Comparing the experimentally induced EPS groups, the best histopathological results and the largest staining with MMP-2 were achieved in Group VI. Furthermore, in all treatment groups (IV, V, VI) more staining with MMP-2 was detected compared to non-treatment groups (I, II, III) but no statistically significant differences were found among all groups. A statistically significant remission was observed in all histopathological parameters, primarily peritoneal thickness in rats that were administered MMF with tacrolimus, compared to rats which were administered tacrolimus only. Conclusion: Concurrent use of tacrolimus and MMF in the treatment of EPS may be a promising approach.
dc.description.sponsorshipNinguno
dc.description.sponsorshipFinanciamiento: Ninguno.
dc.identifier.endpage274
dc.identifier.issn0326-3428
dc.identifier.issn2346-8548
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85127396206
dc.identifier.scopusqualityQ4
dc.identifier.startpage264
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5033
dc.identifier.volume41
dc.identifier.wosWOS:000729709300007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAsoc Regional Dialisis Trasplantes Renales
dc.relation.ispartofRevista De Nefrologia Dialisis Y Trasplante
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectrenal dialysis
dc.subjectperitoneal dialysis
dc.subjectencapsulating peritoneal sclerosis
dc.subjecttacrolimus
dc.subjectmycophenolate mofetil
dc.titleThe effects of tacrolimus and mycophenolate mofetil on regression of encapsulating peritoneal sclerosis in a rat model
dc.title.alternativeEfectos del tacrolimus y el micofenolato mofetil en la regresión de la esclerosis peritoneal encapsulante en ratas
dc.typeArticle

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