An evaluation of trace elements and oxidative stress in patients with benign paroxysmal positional vertigo

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dc.authorid0000-0001-8653-0544
dc.contributor.authorGunizi, Huseyin
dc.contributor.authorSavas, Hasan Basri
dc.date.accessioned2026-01-24T12:29:11Z
dc.date.available2026-01-24T12:29:11Z
dc.date.issued2023
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObjectivesVertigo and Dizziness are a common complaint among the reasons for applying to the ear nose throat clinic. Benign Paroxysmal Positional Vertigo (BPPV) is the most common cause of perpheric vertigo. Oxidative stress is caused by the formation of hydroxyl radicals, superoxide anions and hydrogen peroxide, which are reactive oxygen derivatives (ROS). The aim of this study is to investigate the relationship between complaints and serum trace element and oxidative stress levels in patients with BPPV. MethodsThis study was conducted with 66 adult patients who presented to the ENT policlinic with the complaint of vertigo and were diagnosed with BPPV between May 2020 and September 2020. Blood samples were taken from patients diagnosed with BPPV to measure serum Zn and Cu levels and oxidative stress levels during an attack. ResultsThe mean ages of the study patients and healthy controls were 45.7 +/- 15.1 and 44.7 +/- 13.2. Female / Male ratio were 28(42.5%)/38(57.5%) and 32(48.5%)/34(51.5%) in study and control group. We found serum Cu levels were lower in the patient group (p <0.05). Serum Total Thiol and Native Thiol values were lower in patients with BPPV. Total Thiol results were statistically significant.(p<0.05) Disulfide values were significantly higher in the disease group. (P <0.05). Thiol Oxidized / Thiol Reduced ratio (2243.6 +/- 6.7/343.8 +/- 125.3) was higher in control group. (p<0.05) ConclusionSerum oxidative stress and trace elements play a role in the pathophysiology of BPPV. We present the cut-off values for Cu and Zn in vertigo patients for the first time in the literature. We think that these cut-off values of the trace elements and thiol/disulfide hemostasis can be used clinically by physicians in the etiology, diagnosis and treatment of vertigo.
dc.identifier.doi10.1371/journal.pone.0277960
dc.identifier.issn1932-6203
dc.identifier.issue2
dc.identifier.pmid36812180
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0277960
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5192
dc.identifier.volume18
dc.identifier.wosWOS:000942161600011
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20260121
dc.titleAn evaluation of trace elements and oxidative stress in patients with benign paroxysmal positional vertigo
dc.typeArticle

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