Relationship between serum oxidative stress and blood brain barrier parameters in patients with major depression

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dc.contributor.authorSolak, Hatice
dc.contributor.authorAkkuş, Merve
dc.contributor.authorAydoğan Avşar, Pınar
dc.date.accessioned2026-01-24T12:20:42Z
dc.date.available2026-01-24T12:20:42Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractObjective: Research emphasises the critical role of blood-brain barrier (BBB) integrity in psychiatric disorders. This study aimed to investigate the relationship between serum Zonula occludens protein - 1 (ZO-1) and serum occludin levels, which are blood brain barrier markers, and serum oxLDL levels, which are known to be associated with oxidative stress and inflammation, in patients with major depression. Methods: The study included 44 drug-naïve patients diagnosed with Major Depressive Disorder (MDD) and 48 healthy controls matched for Body Mass Index (BMI), gender, age. Laboratory data, together with concentrations of Ox-LDL, Occludin, ZO-1, were evaluated. The Hamilton Depression Rating Scale (HADRS) was employed to evaluate the severity of depression in the major depression cohort. Result: Compared to healthy controls, patients with major depression exhibited significantly lower serum levels of ZO-1 (p = 0.001) and occludin (p = 0.001), while oxLDL levels were significantly higher (p = 0.001). The differences maintained as significant after corrections for age, sex, smoking, and BMI via ANCOVA (all p = 0.001). A positive correlation was identified between ZO-1 and occludin levels (r = .400, p = 0.001), whereas a negative correlation was found between ZO-1 and oxLDL levels (r = ?.369, p = 0.001). Conclusion: This study's findings indicate that serum oxLDL levels, related with oxidative stress and inflammation in the pathogenesis of MDD, may influence the alteration of serum ZO-1 and occludin levels, recognised as indicators of the BBB. © 2025 Elsevier Ltd
dc.identifier.doi10.1016/j.jpsychires.2025.07.023
dc.identifier.endpage31
dc.identifier.issn0022-3956
dc.identifier.pmid40753795
dc.identifier.scopus2-s2.0-105012127191
dc.identifier.scopusqualityQ1
dc.identifier.startpage25
dc.identifier.urihttps://doi.org/10.1016/j.jpsychires.2025.07.023
dc.identifier.urihttps://hdl.handle.net/20.500.12868/4522
dc.identifier.volume190
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.ispartofJournal of Psychiatric Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20260121
dc.subject1 (ZO-1)
dc.subjectMajor depressive disorder
dc.subjectoccludin
dc.subjectOx-LDL
dc.subjectZonula occludens protein
dc.titleRelationship between serum oxidative stress and blood brain barrier parameters in patients with major depression
dc.typeArticle

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