Essential oils from Melissa officinalis and Citrus reticulata ameliorate testicular inflammation and apoptosis induced by sleep deprivation

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dc.contributor.authorSahin, Melda
dc.contributor.authorOzmen, Ozlem
dc.contributor.authorOzmen, Ismail
dc.date.accessioned2026-01-24T12:31:26Z
dc.date.available2026-01-24T12:31:26Z
dc.date.issued2025
dc.departmentAlanya Alaaddin Keykubat Üniversitesi
dc.description.abstractSleep deprivation is a major risk factor for male infertility, largely via inflammatory and apoptotic pathways, yet effective treatments are limited. This study examined the protective effects of bioactive essential oils from Melissa officinalis and Citrus reticulata against testicular injury induced by total sleep deprivation (TSD). Forty-eight male Sprague Dawley rats were randomly assigned to six groups and exposed to TSD for 20 days using the multiple platform method. Interventions included daily inhalation of individual oils, their combination, or Alprazolam (ALP) as a control. Histopathological and immunohistochemical analyses (Cas-3, CD11b, NF-kappa B) were performed on testes, epididymis, and prostate. TSD caused severe structural degeneration in reproductive organs, with marked upregulation of apoptotic and inflammatory markers. Both essential oils alleviated these changes, while their combination provided superior protection compared to single use. Interestingly, the prostate showed relative resistance to TSD-induced injury compared with testes and epididymis. To our knowledge, this is the first evidence that inhalation of Melissa officinalis and Citrus reticulata essential oils significantly protects against sleep deprivation - induced reproductive toxicity. These findings suggest a safe, non-invasive aromatherapeutic strategy for preserving male fertility under chronic sleep stress.
dc.identifier.doi10.1080/09291016.2025.2593898
dc.identifier.issn0929-1016
dc.identifier.issn1744-4179
dc.identifier.scopus2-s2.0-105022750032
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1080/09291016.2025.2593898
dc.identifier.urihttps://hdl.handle.net/20.500.12868/5879
dc.identifier.wosWOS:001621815900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBiological Rhythm Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20260121
dc.subjectCitrus reticulata
dc.subjectessential oils
dc.subjectmale infertility
dc.subjectMelissa officinalis
dc.subjectsleep deprivation
dc.titleEssential oils from Melissa officinalis and Citrus reticulata ameliorate testicular inflammation and apoptosis induced by sleep deprivation
dc.typeArticle

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